You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NPHS2
Podocin

Protein Summary
Description
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367615
  • ENSP00000356587
  • ENSG00000116218
  • ENST00000367616
  • ENSP00000356588

Symbol
  • PDCN
  • SRN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.75
cellular component
0.7
disease
0.67
cell type or tissue
0.62
gene perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.14   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 461.14   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thrombomodulin measurement
1
1
1
65.1
tumor necrosis factor receptor II measurement
1
1
1
60.7
vitamin D measurement
1
1
1
46.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thrombomodulin measurement
1
65.1
tumor necrosis factor receptor II measurement
1
60.7
vitamin D measurement
1
46.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NPHS2, podocin
VGNC:8438
100615219
Macaque
NPHS2, podocin
100430826
Mouse
MGI:2157018
170484
Rat
RGD:620461
170672
Dog
NPHS2, podocin
VGNC:54153
490323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NPHS2, podocin
Macaque
NPHS2, podocin
Mouse
Rat
Dog
NPHS2, podocin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NP85-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (104)
1 – 10 of 104
NPHS1
Tbio
Novelty: 0.00104742
Score: 0.998
Data Source: Reactome,STRINGDB
CD2AP
Tbio
Novelty: 0.00603034
Score: 0.997
Data Source: STRINGDB
KIRREL1
Tbio
Novelty: 0.03216031
Score: 0.992
Data Source: Reactome,STRINGDB
TRPC6
Tchem
Family: IC
Novelty: 0.00118598
Score: 0.99
Data Source: STRINGDB
NCK1
Tbio
Novelty: 0.00352084
Score: 0.951
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.941
Data Source: STRINGDB
NCK2
Tbio
Novelty: 0.02220251
Score: 0.939
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.934
Data Source: Reactome,STRINGDB
WASL
Tbio
Novelty: 0.0029314
Score: 0.915
Data Source: STRINGDB
PIK3CB
Tchem
Family: Kinase
Novelty: 0.00390277
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  461.14

PubMed score by year
PubTator Score  302.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: