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Tbio
TOR1AIP2
Torsin-1A-interacting protein 2, isoform IFRG15

Protein Summary
Description
One of the two protein isoforms encoded by this gene is a type II integral membrane protein found in the endoplasmic reticulum (ER). The encoded protein is a cofactor for the ATPase TorsinA, regulating the amount of TorsinA present in the ER compared to that found in the nuclear envelope. Defects in this protein are a cause of early onset primary dystonia, a neuromuscular disease. The other isoform encoded by this gene is an interferon alpha responsive protein whose cellular role has yet to be determined. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000482587
  • ENSP00000485355
  • ENSG00000169905

Symbol
  • IFRG15
  • NET9
  • LULL1
  • IFRG15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.88   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.88   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (35)
1 – 10 of 35
TOR1A
Tbio
Novelty: 0.00056274
Score: 0.917
Data Source: STRINGDB
TOR1B
Tbio
Novelty: 0.00611826
Score: 0.813
Data Source: STRINGDB
CCDC84
Tdark
Novelty: 1.44050636
Score: 0.732
Data Source: STRINGDB
PLPP7
Tdark
Family: Enzyme
Novelty: 0.28747179
Score: 0.705
Data Source: STRINGDB
TOR2A
Tbio
Novelty: 0.36991346
Score: 0.705
Data Source: STRINGDB
TOR2A
Tbio
Novelty: 0.36991346
Score: 0.705
Data Source: STRINGDB
TOR3A
Tbio
Novelty: 0.11588309
Score: 0.669
Data Source: STRINGDB
SUN2
Tbio
Novelty: 0.01387591
Score: 0.643
Data Source: STRINGDB
C6orf52
Tdark
Novelty: 1.02810778
Score: 0.626
Data Source: STRINGDB
SYNE3
Tbio
Novelty: 0.06515065
Score: 0.615
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.88

PubMed score by year
PubTator Score  8.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer