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Tchem
CACNA1E
Voltage-dependent R-type calcium channel subunit alpha-1E

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358338
  • ENSP00000351101
  • ENSG00000198216
  • ENST00000367567
  • ENSP00000356539
  • ENST00000367570
  • ENSP00000356542
  • ENST00000367573
  • ENSP00000356545
  • ENST00000621551
  • ENSP00000483914
  • ENST00000621791
  • ENSP00000481619

Symbol
  • CACH6
  • CACNL1A6
  • BII
  • CACH6
  • gm139
  • Cav2.3
  • EIEE69
  • CACNL1A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.85
virus perturbation
0.83
cell type or tissue
0.79
microRNA
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.56   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.56   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
mibefradil
chemical structure image
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
5
5
96.2
self reported educational attainment
2
3
3
94.8
intelligence
3
3
1
5.5
86.4
cognitive function measurement
3
1
3
85.9
unipolar depression
1
1
0
1
82.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
96.2
self reported educational attainment
3
94.8
intelligence
1
5.5
86.4
cognitive function measurement
3
85.9
unipolar depression
0
1
82.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Integration of energy metabolism (R-HSA-163685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Neuronal System
Reactome
Presynaptic depolarization and calcium channel opening
Reactome
Regulation of insulin secretion
Name
Explore in Pharos
Explore in Source
Integration of energy metabolism
Metabolism
Neuronal System
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion
Protein-Protein Interactions (111)
1 – 10 of 111
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.976
Data Source: STRINGDB
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.975
Data Source: STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
Score: 0.967
Data Source: STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
Score: 0.963
Data Source: STRINGDB
CACNA2D3
Tbio
Family: IC
Novelty: 0.05267262
Score: 0.962
Data Source: STRINGDB
CACNA2D2
Tclin
Family: IC
Novelty: 0.02041017
Score: 0.958
Data Source: Reactome,STRINGDB
CACNG4
Tbio
Family: IC
Novelty: 0.15976593
Score: 0.926
Data Source: Reactome,STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.918
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.915
Data Source: STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.895
Data Source: STRINGDB
Publication Statistics
PubMed Score  270.56

PubMed score by year
PubTator Score  207.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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