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Tbio
RGS16
Regulator of G-protein signaling 16

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity). The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367558
  • ENSP00000356529
  • ENSG00000143333

Symbol
  • RGSR
  • RGS-R
  • A28-RGS14
  • A28-RGS14P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
transcription factor perturbation
0.99
PubMedID
0.93
kinase perturbation
0.88
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.21   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.21   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
2
2
1.2
98.9
circadian rhythm
3
2
2
1.4
88.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.2
98.9
circadian rhythm
2
1.4
88.1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
G alpha (z) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (z) signalling events
GPCR downstream signalling
Signal Transduction
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (26)
1 – 10 of 26
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.975
Data Source: STRINGDB
GNAI3
Tbio
Novelty: 0.03484857
Score: 0.964
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.961
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.937
Data Source: STRINGDB
GDE1
Tbio
Family: Enzyme
Novelty: 0.05854843
Score: 0.927
Data Source: STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
Score: 0.879
Data Source: STRINGDB
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.778
Data Source: STRINGDB
ATE1
Tbio
Family: Enzyme
Novelty: 0.01672896
Score: 0.752
Data Source: STRINGDB
PDC
Tbio
Novelty: 0.00306842
Score: 0.715
Data Source: STRINGDB
F13B
Tbio
Novelty: 0.00562478
Score: 0.624
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.21

PubMed score by year
PubTator Score  35.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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