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Tbio
DHX9
ATP-dependent RNA helicase A

Protein Summary
Description
Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:9111062, PubMed:11416126, PubMed:12711669, PubMed:15355351, PubMed:16680162, PubMed:17531811, PubMed:20669935, PubMed:21561811, PubMed:24049074, PubMed:25062910, PubMed:24990949, PubMed:28221134). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367549
  • ENSP00000356520
  • ENSG00000135829

Symbol
  • DDX9
  • LKP
  • NDH2
  • LKP
  • RHA
  • DDX9
  • NDH2
  • NDHII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
molecular function
1
protein domain
0.97
protein complex
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 831.9   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 831.9   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Immune System
Innate Immune System
Metabolism of RNA
Gene Ontology Terms (100)
Items per page:
10
1 – 10 of 36
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (466)
1 – 10 of 466
PRMT8
Tchem
Family: Epigenetic
Novelty: 0.04213384
p_int: 0.99778099
p_ni: 0.00221901
Score: 0.441
Data Source: BioPlex,STRINGDB
HNRNPK
Tbio
Novelty: 0.00354731
Score: 0.991
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.99
Data Source: STRINGDB
HNRNPR
Tbio
Novelty: 0.06568708
Score: 0.989
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.988
Data Source: STRINGDB
HNRNPM
Tbio
Novelty: 0.0125566
Score: 0.988
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.988
Data Source: STRINGDB
HNRNPL
Tbio
Novelty: 0.01048413
Score: 0.987
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.986
Data Source: STRINGDB
DDX5
Tbio
Family: Enzyme
Novelty: 0.00637984
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  831.90

PubMed score by year
PubTator Score  120.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer