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Tbio
TPR
Nucleoprotein TPR

Protein Summary
Description
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367478
  • ENSP00000356448
  • ENSG00000047410
  • ENST00000613151
  • ENSP00000483425
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein complex
1
drug perturbation
0.96
cellular component
0.95
co-expressed gene
0.95


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.68   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.68   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocated promoter region, nuclear basket protein
VGNC:9903
457588
Mouse
MGI:1922066
108989
Rat
RGD:1310664
304862
Dog
translocated promoter region, nuclear basket protein
VGNC:53807
480045
Horse
translocated promoter region, nuclear basket protein
VGNC:50899
100049850
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocated promoter region, nuclear basket protein
Mouse
Rat
Dog
translocated promoter region, nuclear basket protein
Horse
translocated promoter region, nuclear basket protein
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12270-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (72)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Gene Ontology Terms (45)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (348)
1 – 10 of 348
ZC3HC1
Tbio
Novelty: 0.089692
p_int: 0.991915462
p_ni: 0.008084538
Score: 0.407
Data Source: BioPlex,STRINGDB
NUP153
Tbio
Novelty: 0.00696568
Score: 0.994
Data Source: STRINGDB
NUP107
Tbio
Novelty: 0.01994155
Score: 0.992
Data Source: STRINGDB
NUP98
Tbio
Family: Enzyme
Novelty: 0.00401452
Score: 0.991
Data Source: STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
Score: 0.987
Data Source: STRINGDB
NUP205
Tbio
Novelty: 0.06778513
Score: 0.985
Data Source: STRINGDB
NUP93
Tbio
Novelty: 0.0248311
Score: 0.984
Data Source: STRINGDB
NXF1
Tbio
Novelty: 0.00642439
Score: 0.983
Data Source: STRINGDB
NUP62
Tbio
Novelty: 0.01432724
Score: 0.982
Data Source: STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00484823
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  215.68

PubMed score by year
PubTator Score  372.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer