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Tbio
NAV1
Neuron navigator 1

Protein Summary
Description
May be involved in neuronal migration. This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367295
  • ENSP00000356264
  • ENSG00000134369
  • ENST00000367296
  • ENSP00000356265

Symbol
  • KIAA1151
  • KIAA1213
  • POMFIL3
  • STEERIN1
  • POMFIL3
  • UNC53H1
  • STEERIN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
drug perturbation
0.96
virus perturbation
0.88
PubMedID
0.87
small molecule perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.49   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.49   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
3
2
0
1
81.3
1
1
1
77.9
heel bone mineral density
2
1
2
74.9
intelligence
1
1
0
6.2
73.9
body mass index
4
1
6
50.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1
81.3
1
77.9
heel bone mineral density
2
74.9
intelligence
0
6.2
73.9
body mass index
6
50.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuron navigator 1
VGNC:11553
457622
Macaque
neuron navigator 1
100426408
Mouse
MGI:2183683
215690
Rat
RGD:1590261
685707
Dog
neuron navigator 1
VGNC:43629
490238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuron navigator 1
Macaque
neuron navigator 1
Mouse
Rat
Dog
neuron navigator 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NEY1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (69)
1 – 10 of 69
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.999999706
p_ni: 2.93e-7
Score: 0.656
Data Source: BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty: 0.01845286
p_int: 0.999991232
p_ni: 0.000008768
Data Source: BioPlex
COG6
Tbio
Novelty: 0.02874093
p_int: 0.999978745
p_ni: 0.000021171
p_wrong: 8.4e-8
Score: 0.343
Data Source: BioPlex,STRINGDB
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.999971874
p_ni: 0.000028126
Score: 0.311
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999958423
p_ni: 0.000041577
Data Source: BioPlex
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.999951262
p_ni: 0.000048738
Data Source: BioPlex
NUP62CL
Tdark
Novelty: 2.93223607
p_int: 0.999598981
p_ni: 0.000399825
p_wrong: 0.000001194
Data Source: BioPlex
RCC1
Tbio
Novelty: 0.00260884
p_int: 0.997381244
p_ni: 0.001373996
p_wrong: 0.001244759
Score: 0.228
Data Source: BioPlex,STRINGDB
PDCD1
Tclin
Novelty: 0.000448
p_int: 0.907207824
p_ni: 0.01747041
p_wrong: 0.075321767
Data Source: BioPlex
MAP3K14
Tchem
Family: Kinase
Novelty: 0.0350173
p_int: 0.83075281
p_ni: 0.165095924
p_wrong: 0.004151266
Score: 0.345
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  240.49

PubMed score by year
PubTator Score  130.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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