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Tbio
UBE2T
Ubiquitin-conjugating enzyme E2 T

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386). The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367274
  • ENSP00000356243
  • ENSG00000077152
  • ENST00000646651
  • ENSP00000494957

Symbol
  • FANCT
  • PIG50
  • HSPC150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
small molecule perturbation
0.75
PubMedID
0.7
transcription factor binding site profile
0.69
histone modification site profile
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.68   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.68   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 T
VGNC:7020
457628
Macaque
ubiquitin conjugating enzyme E2 T
705911
Mouse
MGI:1914446
67196
Rat
RGD:1310816
360847
Dog
ubiquitin conjugating enzyme E2 T
VGNC:48066
607154
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 T
Macaque
ubiquitin conjugating enzyme E2 T
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 T
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (77)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (233)
1 – 10 of 233
FANCB
Tbio
Novelty: 0.00268111
p_int: 0.999989244
p_ni: 0.000002089
p_wrong: 0.000008667
Score: 0.984
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.993198053
p_ni: 0.006801062
p_wrong: 8.85e-7
Data Source: BioPlex
ZNF277
Tbio
Novelty: 0.21739031
p_int: 0.97327444
p_ni: 0.026669107
p_wrong: 0.000056454
Score: 0.232
Data Source: BioPlex,STRINGDB
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.965876043
p_ni: 0.033786967
p_wrong: 0.00033699
Data Source: BioPlex
FGB
Tbio
Novelty: 0.00437751
p_int: 0.961971673
p_ni: 0.038001243
p_wrong: 0.000027084
Data Source: BioPlex
OIP5
Tbio
Novelty: 0.02546471
p_int: 0.951274419
p_ni: 0.048525339
p_wrong: 0.000200242
Score: 0.784
Data Source: BioPlex,STRINGDB
MBD5
Tbio
Family: Epigenetic
Novelty: 0.03015349
p_int: 0.951274419
p_ni: 0.048525339
p_wrong: 0.000200242
Score: 0.168
Data Source: BioPlex,STRINGDB
C11orf65
Tdark
Novelty: 0.61247408
p_int: 0.931836625
p_ni: 0.067252343
p_wrong: 0.000911032
Score: 0.282
Data Source: BioPlex,STRINGDB
CDK5R1
Tchem
Family: Enzyme
Novelty: 0.01065962
p_int: 0.931836625
p_ni: 0.067252343
p_wrong: 0.000911032
Score: 0.204
Data Source: BioPlex,STRINGDB
FAAP100
Tdark
Novelty: 0.1698504
p_int: 0.795709707
p_ni: 0.204272079
p_wrong: 0.000018213
Score: 0.983
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.68

PubMed score by year
PubTator Score  17.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer