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Tbio
SERAC1
Protein SERAC1

Protein Summary
Description
Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway. The protein encoded by this gene is a phosphatidylglycerol remodeling protein found at the interface of mitochondria and endoplasmic reticula, where it mediates phospholipid exchange. The encoded protein plays a major role in mitochondrial function and intracellular cholesterol trafficking. Defects in this gene are a cause of 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367101
  • ENSP00000356068
  • ENSG00000122335
  • ENST00000367104
  • ENSP00000356071
  • ENST00000647468
  • ENSP00000496731
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor perturbation
0.74
tissue sample
0.67
microRNA
0.61
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.06   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.06   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (70)
1 – 10 of 70
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01036678
p_int: 0.83655615
p_ni: 0.16344385
Score: 0.224
Data Source: BioPlex,STRINGDB
DNAJC19
Tbio
Family: Enzyme
Novelty: 0.0440806
Score: 0.714
Data Source: STRINGDB
BCS1L
Tbio
Family: Enzyme
Novelty: 0.00258512
Score: 0.694
Data Source: STRINGDB
MROH6
Tdark
Novelty: 6
Score: 0.671
Data Source: STRINGDB
AGK
Tbio
Family: Enzyme
Novelty: 0.01192407
Score: 0.665
Data Source: STRINGDB
FGFBP2
Tbio
Novelty: 0.15734479
Score: 0.65
Data Source: STRINGDB
HEATR9
Tdark
Score: 0.645
Data Source: STRINGDB
TMEM70
Tbio
Novelty: 0.04069176
Score: 0.636
Data Source: STRINGDB
CHKB
Tbio
Family: Kinase
Novelty: 0.01524905
Score: 0.635
Data Source: STRINGDB
TOGARAM1
Tdark
Novelty: 0.51282051
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.06

PubMed score by year
PubTator Score  20.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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