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Tbio
DYNLT1
Dynein light chain Tctex-type 1

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367089
  • ENSP00000356056
  • ENSG00000146425

Symbol
  • TCTEL1
  • TCTEX-1
  • TCTEX1
  • CW-1
  • TCTEL1
  • tctex-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.91
virus perturbation
0.88
cellular component
0.8
biological process
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.91   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.91   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (33)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (184)
1 – 10 of 184
DYNC1H1
Tbio
Novelty: 0.0098543
Score: 0.996
Data Source: STRINGDB
DYNC1LI2
Tbio
Novelty: 0.17381295
Score: 0.99
Data Source: STRINGDB
DYNLRB1
Tbio
Novelty: 0.01342103
Score: 0.989
Data Source: STRINGDB
DYNC1LI1
Tbio
Novelty: 0.02164556
Score: 0.988
Data Source: STRINGDB
DYNLL1
Tbio
Novelty: 0.00397334
Score: 0.981
Data Source: STRINGDB
DYNC1I1
Tbio
Novelty: 0.12175372
Score: 0.98
Data Source: STRINGDB
DYNC1I2
Tbio
Novelty: 0.00228615
Score: 0.973
Data Source: STRINGDB
DYNLL2
Tbio
Novelty: 0.11209457
Score: 0.959
Data Source: STRINGDB
WDR34
Tbio
Novelty: 0.05515847
Score: 0.954
Data Source: STRINGDB
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  313.91

PubMed score by year
PubTator Score  136.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer