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Tbio
EZR
Ezrin

Protein Summary
Description
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337147
  • ENSP00000338934
  • ENSG00000092820
  • ENST00000367075
  • ENSP00000356042

Symbol
  • VIL2
  • CVL
  • CVIL
  • VIL2
  • HEL-S-105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
hub protein
1
kinase
1
protein domain
1
disease perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 841.42   (req: < 5)
Gene RIFs: 333   (req: <= 3)
Antibodies: 1346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 841.42   (req: >= 5)
Gene RIFs: 333   (req: > 3)
Antibodies: 1346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair colour measurement
1
1
1
89.2
hair color
1
1
0
1.1
68.5
testosterone measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair colour measurement
1
89.2
hair color
0
1.1
68.5
testosterone measurement
1
54.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ezrin
VGNC:2784
463100
Macaque
ezrin
704716
Mouse
MGI:98931
22350
Rat
RGD:621161
54319
Dog
ezrin
VGNC:40542
484056
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ezrin
Macaque
ezrin
Mouse
Rat
Dog
ezrin
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15311-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (178)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Netrin-1 signaling
Reactome
Recycling pathway of L1
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Netrin-1 signaling
Recycling pathway of L1
Gene Ontology Terms (93)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (291)
1 – 10 of 291
RDX
Tbio
Novelty: 0.00236103
p_int: 0.999995925
p_ni: 0.000004075
Score: 0.938
Data Source: BioPlex,STRINGDB
ZNF622
Tbio
Novelty: 0.26258288
p_int: 0.999784924
p_ni: 0.000203892
p_wrong: 0.000011185
Data Source: BioPlex
MSN
Tbio
Novelty: 0.00178275
p_int: 0.999650763
p_ni: 0.000349237
Score: 0.948
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.98346557
p_ni: 0.01653443
Data Source: BioPlex
MISP
Tbio
Novelty: 0.02030151
p_int: 0.957822795
p_ni: 0.042177205
Score: 0.297
Data Source: BioPlex,STRINGDB
BCR
Tclin
Novelty: 0.00127709
p_int: 0.863788225
p_ni: 0.13621177
p_wrong: 4e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.856616328
p_ni: 0.143383672
Score: 0.939
Data Source: BioPlex,STRINGDB
TSPAN33
Tbio
Novelty: 0.17463296
p_int: 0.778813037
p_ni: 0.221186963
Score: 0.417
Data Source: BioPlex,STRINGDB
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.00357766
Score: 0.998
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  841.42

PubMed score by year
PubTator Score  446.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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