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Tchem
ACAT2
Acetyl-CoA acetyltransferase, cytosolic

Protein Summary
Description
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367048
  • ENSP00000356015
  • ENSG00000120437

Symbol
  • ACTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
pathway
0.93
protein domain
0.92
histone modification site profile
0.88
virus perturbation
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.85   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.85   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3890942
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA acetyltransferase 2
VGNC:2635
741276
Macaque
acetyl-CoA acetyltransferase 2
100427660
Mouse
MGI:109182
224530
Rat
RGD:1359366
308100
Dog
acetyl-CoA acetyltransferase 2
VGNC:37499
484063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acetyl-CoA acetyltransferase 2
Macaque
acetyl-CoA acetyltransferase 2
Mouse
Rat
Dog
acetyl-CoA acetyltransferase 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BWD1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Protein-Protein Interactions (133)
1 – 10 of 133
MLST8
Tbio
Novelty: 0.00423122
p_int: 0.89766563
p_ni: 0.10233437
Score: 0.359
Data Source: BioPlex,STRINGDB
ACAT1
Tchem
Family: Enzyme
Novelty: 0.00908928
p_int: 0.853883349
p_ni: 0.146116651
Score: 0.947
Data Source: BioPlex,STRINGDB
HADH
Tbio
Family: Enzyme
Novelty: 0.00368073
Score: 0.991
Data Source: STRINGDB
HMGCS1
Tchem
Family: Enzyme
Novelty: 0.01089288
Score: 0.989
Data Source: STRINGDB
HMGCS2
Tbio
Family: Enzyme
Novelty: 0.0103808
Score: 0.98
Data Source: STRINGDB
HADHA
Tbio
Novelty: 0.00385746
Score: 0.973
Data Source: STRINGDB
EHHADH
Tbio
Novelty: 0.00878193
Score: 0.971
Data Source: STRINGDB
OXCT1
Tbio
Family: Enzyme
Novelty: 0.00283394
Score: 0.961
Data Source: STRINGDB
ACADS
Tbio
Family: Enzyme
Novelty: 0.00841051
Score: 0.958
Data Source: STRINGDB
HMGCL
Tbio
Family: Enzyme
Novelty: 0.02741994
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.85

PubMed score by year
PubTator Score  67.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer