You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
H3F3A
Histone H3.3

Protein Summary
Description
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254810
  • ENSP00000254810
  • ENSG00000132475
  • ENST00000366813
  • ENSP00000355778
  • ENSG00000163041
  • ENST00000366815
  • ENSP00000355780
  • ENST00000366816
  • ENSP00000355781
  • ENST00000586607
  • ENSP00000466020
  • ENST00000587560
  • ENSP00000468714
  • ENST00000589599
  • ENSP00000465813

Symbol
  • H3.3A
  • H3F3
  • H3F3
  • H3.3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.98
kinase
0.98
transcription factor perturbation
0.98
transcription factor binding site profile
0.97
kinase perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.58   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 501   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.58   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
98.3
low density lipoprotein cholesterol measurement
2
1
2
78.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
98.3
low density lipoprotein cholesterol measurement
2
78.2
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1097686
15078
Pig
H3 histone, family 3A
396970
Opossum
H3 histone, family 3B
100022653
Zebrafish
ZDB-GENE-040426-1928
406269
C. elegans
181057
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Pig
H3 histone, family 3A
Opossum
H3 histone, family 3B
Zebrafish
C. elegans
Protein Data Bank (51)
1 – 5 of 51
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (68)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (40)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (263)
1 – 10 of 263
LACC1
Tbio
Family: Enzyme
Novelty: 0.03928871
p_int: 0.999999933
p_ni: 6.6e-8
p_wrong: 1e-9
Data Source: BioPlex
KIF3A
Tbio
Novelty: 0.00555124
p_int: 0.999999876
p_ni: 6.3e-8
p_wrong: 6.2e-8
Data Source: BioPlex
SGO2
Tbio
Novelty: 0.05544423
p_int: 0.999656444
p_ni: 2.93e-7
p_wrong: 0.000343263
Data Source: BioPlex
NASP
Tbio
Novelty: 0.00902599
p_int: 0.990936769
p_ni: 3.5e-8
p_wrong: 0.009063196
Score: 0.647
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
Score: 0.993
Data Source: Reactome,STRINGDB
HIST1H3A
Tbio
Novelty: 0.00991842
Score: 0.989
Data Source: Reactome,STRINGDB
HIST3H3
Tbio
Novelty: 0.04915012
Score: 0.989
Data Source: STRINGDB
CENPA
Tbio
Novelty: 0.00154245
Score: 0.985
Data Source: STRINGDB
UBN1
Tbio
Novelty: 0.01703683
Score: 0.985
Data Source: STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  177.58

PubMed score by year
PubTator Score  73.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: