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Tbio
B3GALNT2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

Protein Summary
Description
Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. This gene encodes a member of the glycosyltransferase 31 family. The encoded protein synthesizes GalNAc:beta-1,3GlcNAc, a novel carbohydrate structure, on N- and O-glycans. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313984
  • ENSP00000315678
  • ENSG00000162885
  • ENST00000366600
  • ENSP00000355559
  • ENST00000635244
  • ENSP00000489219
  • ENSG00000282880
  • ENST00000635453
  • ENSP00000489342

Symbol
  • MDDGA11
  • B3GalNAc-T2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
transcription factor binding site profile
0.92
histone modification site profile
0.88
transcription factor perturbation
0.8
microRNA
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.72   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.72   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
28
body mass index
1
1
1
28
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
28
body mass index
1
28
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,3-N-acetylgalactosaminyltransferase 2
VGNC:454
469715
Mouse
MGI:2145517
97884
Rat
RGD:1306946
291212
Dog
beta-1,3-N-acetylgalactosaminyltransferase 2
VGNC:38332
479196
Horse
beta-1,3-N-acetylgalactosaminyltransferase 2
VGNC:15723
100058647
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,3-N-acetylgalactosaminyltransferase 2
Mouse
Rat
Dog
beta-1,3-N-acetylgalactosaminyltransferase 2
Horse
beta-1,3-N-acetylgalactosaminyltransferase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NCR0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
Post-translational protein modification
Protein-Protein Interactions (45)
1 – 10 of 45
OS9
Tbio
Novelty: 0.01490339
p_int: 0.99837769
p_ni: 0.00162231
p_wrong: 1e-9
Score: 0.166
Data Source: BioPlex,STRINGDB
CHST8
Tbio
Family: Enzyme
Novelty: 0.03489772
p_int: 0.997527901
p_ni: 0.002472099
Score: 0.194
Data Source: BioPlex,STRINGDB
PARP16
Tbio
Family: Enzyme
Novelty: 0.09651799
p_int: 0.992806799
p_ni: 0.007193201
Score: 0.188
Data Source: BioPlex,STRINGDB
EIF2B2
Tbio
Novelty: 0.03253919
p_int: 0.922065259
p_ni: 0.07782797
p_wrong: 0.000106771
Score: 0.179
Data Source: BioPlex,STRINGDB
AMIGO1
Tbio
Novelty: 0.00864791
p_int: 0.819234015
p_ni: 0.180557789
p_wrong: 0.000208195
Data Source: BioPlex
GFRA3
Tbio
Novelty: 0.10149548
p_int: 0.818285543
p_ni: 0.181519436
p_wrong: 0.000195021
Data Source: BioPlex
YY1AP1
Tbio
Novelty: 0.06862573
p_int: 0.762471958
p_ni: 0.237509159
p_wrong: 0.000018883
Data Source: BioPlex
IDS
Tbio
Family: Enzyme
Novelty: 0.00733996
p_int: 0.758222383
p_ni: 0.241777604
p_wrong: 1.3e-8
Score: 0.351
Data Source: BioPlex,STRINGDB
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.75012919
p_ni: 0.249865071
p_wrong: 0.000005739
Data Source: BioPlex
POMK
Tbio
Family: Kinase
Novelty: 0.09340344
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.72

PubMed score by year
PubTator Score  7.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer