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Tbio
MTR
Methionine synthase

Protein Classes
Protein Summary
Description
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366577
  • ENSP00000355536
  • ENSG00000116984
  • ENST00000535889
  • ENSP00000441845

Symbol
  • MS
  • HMAG
  • cblG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
virus perturbation
0.92
biological term
0.81
molecular function
0.79
disease
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1355.07   (req: < 5)
Gene RIFs: 186   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1355.07   (req: >= 5)
Gene RIFs: 186   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
1
1
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
57.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-methyltetrahydrofolate-homocysteine methyltransferase
VGNC:1338
457844
Macaque
5-methyltetrahydrofolate-homocysteine methyltransferase
717582
Mouse
MGI:894292
238505
Rat
RGD:621283
81522
Dog
5-methyltetrahydrofolate-homocysteine methyltransferase
VGNC:43491
479190
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-methyltetrahydrofolate-homocysteine methyltransferase
Macaque
5-methyltetrahydrofolate-homocysteine methyltransferase
Mouse
Rat
Dog
5-methyltetrahydrofolate-homocysteine methyltransferase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99707-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (40)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Reactome
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Reactome
Defects in cobalamin (B12) metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defects in cobalamin (B12) metabolism
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (102)
1 – 10 of 102
INSYN2
Tdark
Novelty: 2.55244594
p_int: 0.977819887
p_ni: 0.022180113
Data Source: BioPlex
AKAP13
Tbio
Family: Enzyme
Novelty: 0.00726267
p_int: 0.973033889
p_ni: 0.026966111
Score: 0.547
Data Source: BioPlex,STRINGDB
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.940998113
p_ni: 0.059001887
Data Source: BioPlex
LINC01587
Tdark
Novelty: 0.48128342
p_int: 0.82455828
p_ni: 0.17544172
Score: 0.169
Data Source: BioPlex,STRINGDB
IQCF1
Tdark
Novelty: 0.78525464
p_int: 0.798867618
p_ni: 0.201132382
Data Source: BioPlex
LPCAT1
Tbio
Family: Enzyme
Novelty: 0.01441133
p_int: 0.77719851
p_ni: 0.22280149
Score: 0.332
Data Source: BioPlex,STRINGDB
SPATA5L1
Tdark
Family: Enzyme
Novelty: 0.5393372
p_int: 0.75330537
p_ni: 0.24669463
Score: 0.189
Data Source: BioPlex,STRINGDB
MTRR
Tbio
Family: Enzyme
Novelty: 0.00231914
Score: 0.996
Data Source: Reactome,STRINGDB
MTHFR
Tbio
Family: Enzyme
Novelty: 0.00018162
Score: 0.995
Data Source: STRINGDB
MMADHC
Tbio
Novelty: 0.02299238
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  1355.07

PubMed score by year
PubTator Score  382.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer