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Tclin
RYR2
Ryanodine receptor 2

Protein Summary
Description
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366574
  • ENSP00000355533
  • ENSG00000198626

Symbol
  • RyR
  • ARVC2
  • ARVD2
  • RYR-2
  • VTSIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
trait
1
cellular component
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1407.84   (req: < 5)
Gene RIFs: 146   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1407.84   (req: >= 5)
Gene RIFs: 146   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 53
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
79.2
risk-taking behaviour
1
2
2
24.1
forced expiratory volume
1
1
0
52.2
18.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
79.2
risk-taking behaviour
2
24.1
forced expiratory volume
0
52.2
18.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ryanodine receptor 2
VGNC:6990
457846
Macaque
ryanodine receptor 2
717179
Mouse
MGI:99685
20191
Rat
RGD:620314
689560
Dog
ryanodine receptor 2
VGNC:45822
403615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ryanodine receptor 2
Macaque
ryanodine receptor 2
Mouse
Rat
Dog
ryanodine receptor 2
Protein Structure (1 Structure, 19 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Muscle contraction
Stimuli-sensing channels
Gene Ontology Terms (66)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (217)
1 – 10 of 217
FKBP1B
Tchem
Family: Enzyme
Novelty: 0.00541222
Score: 0.999
Data Source: STRINGDB
TRDN
Tbio
Novelty: 0.00501554
Score: 0.988
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.985
Data Source: STRINGDB
ASPH
Tbio
Family: Enzyme
Novelty: 0.00291455
Score: 0.982
Data Source: STRINGDB
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
Score: 0.955
Data Source: STRINGDB
NOS1
Tchem
Family: Enzyme
Novelty: 0.00032064
Score: 0.926
Data Source: STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
Score: 0.926
Data Source: STRINGDB
CASQ2
Tbio
Novelty: 0.00775794
Score: 0.915
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.911
Data Source: STRINGDB
RAPGEF4
Tchem
Novelty: 0.00235788
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  1407.84

PubMed score by year
PubTator Score  707.28

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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