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Tbio
PAX9
Paired box protein Pax-9

Protein Summary
Description
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361487
  • ENSP00000355245
  • ENSG00000198807
  • ENST00000402703
  • ENSP00000384817

Symbol
  • STHAG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
gene perturbation
0.98
virus perturbation
0.76
biological process
0.74
PubMedID
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.15   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.15   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
0
1.1
79
prostate carcinoma
1
1
0
1.1
44.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
79
prostate carcinoma
0
1.1
44.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paired box 9
737458
Macaque
paired box 9
100429091
Mouse
MGI:97493
18511
Rat
RGD:1560838
362741
Dog
paired box 9
VGNC:44280
490654
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paired box 9
Macaque
paired box 9
Mouse
Rat
Dog
paired box 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P55771-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Nuclear Receptors
Name
Explore in Pharos
Explore in Source
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Nuclear Receptors
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (78)
1 – 10 of 78
MSX1
Tbio
Family: TF
Novelty: 0.00176212
Score: 0.969
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00047387
Score: 0.811
Data Source: STRINGDB
NKX2-8
Tbio
Family: TF
Novelty: 0.08397416
Score: 0.785
Data Source: STRINGDB
OSR2
Tbio
Family: TF
Novelty: 0.02194344
Score: 0.777
Data Source: STRINGDB
NKX3-2
Tbio
Family: TF
Novelty: 0.01804711
Score: 0.777
Data Source: STRINGDB
KLF4
Tbio
Family: TF
Novelty: 0.00076828
Score: 0.775
Data Source: STRINGDB
FGF8
Tbio
Novelty: 0.00155113
Score: 0.737
Data Source: STRINGDB
PRRX2
Tbio
Family: TF
Novelty: 0.08230504
Score: 0.731
Data Source: STRINGDB
KDM5B
Tchem
Family: TF; Epigenetic
Novelty: 0.00610414
Score: 0.727
Data Source: STRINGDB
BARX1
Tbio
Family: TF
Novelty: 0.02163397
Score: 0.69
Data Source: STRINGDB
Publication Statistics
PubMed Score  186.15

PubMed score by year
PubTator Score  115.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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