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Tbio
KRT19
Keratin, type I cytoskeletal 19

Protein Summary
Description
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
virus perturbation
0.95
gene perturbation
0.91
PubMedID
0.84
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2229.99   (req: < 5)
Gene RIFs: 196   (req: <= 3)
Antibodies: 2870   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2229.99   (req: >= 5)
Gene RIFs: 196   (req: > 3)
Antibodies: 2870   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Developmental Biology (R-HSA-1266738)

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Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Protein-Protein Interactions (212)
1 – 10 of 212
KRT8
Tbio
Novelty: 0.00093008
Score: 0.97
Data Source: STRINGDB
KRT18
Tbio
Novelty: 0.00069055
Score: 0.956
Data Source: STRINGDB
KRT7
Tbio
Novelty: 0.00039796
Score: 0.955
Data Source: STRINGDB
KRT5
Tbio
Novelty: 0.00072336
Score: 0.938
Data Source: STRINGDB
KRT4
Tbio
Novelty: 0.00434637
Score: 0.938
Data Source: STRINGDB
KRT6B
Tbio
Novelty: 0.00152754
Score: 0.937
Data Source: STRINGDB
KRT3
Tbio
Novelty: 0.00489796
Score: 0.935
Data Source: STRINGDB
KRT1
Tbio
Novelty: 0.00278467
Score: 0.935
Data Source: STRINGDB
KRT78
Tbio
Novelty: 0.08006367
Score: 0.934
Data Source: STRINGDB
KRT80
Tbio
Novelty: 0.08480792
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  2229.99

PubMed score by year
PubTator Score  1692.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer