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Tbio
CTNNBL1
Beta-catenin-like protein 1

Protein Summary
Description
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361383
  • ENSP00000355050
  • ENSG00000132792
  • ENST00000373469
  • ENSP00000362568
  • ENST00000373473
  • ENSP00000362572
  • ENST00000405275
  • ENSP00000384355
  • ENST00000628103
  • ENSP00000487198

Symbol
  • C20orf33
  • NAP
  • P14L
  • PP8304
  • C20orf33
  • dJ633O20.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
cell type or tissue
0.77
histone modification site profile
0.74
transcription factor perturbation
0.74
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.75   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.75   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
22.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
22.6
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (289)
1 – 10 of 289
ZNF394
Tdark
Family: TF
Novelty: 1.32902012
p_int: 0.999995697
p_ni: 0.000004303
Score: 0.187
Data Source: BioPlex,STRINGDB
ZNF331
Tbio
Family: TF
Novelty: 0.05976217
p_int: 0.999994241
p_ni: 0.000005759
Data Source: BioPlex
CWC15
Tbio
Novelty: 0.00205068
p_int: 0.999973582
p_ni: 0.000026418
Score: 0.999
Data Source: BioPlex,STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
p_int: 0.999598586
p_ni: 0.000401409
p_wrong: 4e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
THAP2
Tdark
Family: TF
Novelty: 0.21339518
p_int: 0.999395263
p_ni: 0.000604734
p_wrong: 2e-9
Score: 0.295
Data Source: BioPlex,STRINGDB
CXCL14
Tbio
Novelty: 0.00606628
p_int: 0.999312325
p_ni: 0.000684821
p_wrong: 0.000002854
Data Source: BioPlex
CLEC3A
Tdark
Novelty: 0.21498836
p_int: 0.999133728
p_ni: 0.000591421
p_wrong: 0.000274851
Score: 0.499
Data Source: BioPlex,STRINGDB
HOXB5
Tbio
Family: TF
Novelty: 0.01119871
p_int: 0.998641051
p_ni: 0.001284175
p_wrong: 0.000074775
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.998519212
p_ni: 0.001394258
p_wrong: 0.00008653
Data Source: BioPlex
FGB
Tbio
Novelty: 0.00437751
p_int: 0.997258964
p_ni: 0.002717209
p_wrong: 0.000023828
Data Source: BioPlex
Publication Statistics
PubMed Score  51.75

PubMed score by year
PubTator Score  141.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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