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Tbio
CNTNAP2
Contactin-associated protein-like 2

Protein Summary
Description
Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361727
  • ENSP00000354778
  • ENSG00000174469
  • ENST00000463592
  • ENSP00000486292
  • ENST00000613345
  • ENSP00000481057
  • ENSG00000278728
  • ENST00000649351
  • ENSP00000496805

Symbol
  • CASPR2
  • KIAA0868
  • CDFE
  • NRXN4
  • AUTS15
  • CASPR2
  • PTHSL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.97
transcription factor perturbation
0.94
PubMedID
0.86
cellular component
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.39   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.39   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
95.3
2
2
0
6
62.6
smoking status measurement
3
1
0
9.4
53.6
low density lipoprotein cholesterol measurement
3
1
0
9.4
53.6
gut microbiome measurement
1
1
1
50
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
95.3
0
6
62.6
smoking status measurement
0
9.4
53.6
low density lipoprotein cholesterol measurement
0
9.4
53.6
gut microbiome measurement
1
50
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
contactin associated protein like 2
574172
Mouse
MGI:1914047
66797
Horse
contactin associated protein like 2
VGNC:16701
100060296
Anole lizard
contactin associated protein like 2
100562824
Species
Name
OMA
EggNOG
Inparanoid
Macaque
contactin associated protein like 2
Mouse
Horse
contactin associated protein like 2
Anole lizard
contactin associated protein like 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UHC6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (32)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (139)
1 – 10 of 139
CNTN2
Tbio
Novelty: 0.00213251
Score: 0.987
Data Source: STRINGDB
LGI1
Tbio
Novelty: 0.00204066
Score: 0.927
Data Source: STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
Score: 0.905
Data Source: STRINGDB
KCNA2
Tclin
Family: IC
Novelty: 0.00164601
Score: 0.894
Data Source: STRINGDB
FOXP2
Tbio
Family: TF
Novelty: 0.00190504
Score: 0.841
Data Source: STRINGDB
NLGN4X
Tbio
Family: Enzyme
Novelty: 0.01004489
Score: 0.793
Data Source: STRINGDB
NLGN3
Tbio
Family: Enzyme
Novelty: 0.00819625
Score: 0.767
Data Source: STRINGDB
EPB41
Tbio
Novelty: 0.0013288
Score: 0.766
Data Source: STRINGDB
DPYSL5
Tbio
Family: Enzyme
Novelty: 0.0052536
Score: 0.761
Data Source: STRINGDB
NFASC
Tbio
Novelty: 0.00545331
Score: 0.758
Data Source: STRINGDB
Publication Statistics
PubMed Score  464.39

PubMed score by year
PubTator Score  228.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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