You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC39A13
Zinc transporter ZIP13

Protein Summary
Description
Acts as a zinc-influx transporter. This gene encodes a member of the LIV-1 subfamily of the ZIP transporter family. The encoded transmembrane protein functions as a zinc transporter. Mutations in this gene have been associated with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome. Alternate transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354884
  • ENSP00000346956
  • ENSG00000165915
  • ENST00000362021
  • ENSP00000354689

Symbol
  • ZIP13
  • ZIP13
  • SCDEDS
  • EDSSPD3
  • LZT-Hs9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
kinase perturbation
0.84
histone modification site profile
0.72
transcription factor
0.7
molecular function
0.6


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.39   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.39   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
1
86
waist circumference
1
1
2
32.6
alcohol use disorder measurement
1
1
0
5.8
32
hip circumference
1
1
1
28.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
86
waist circumference
2
32.6
alcohol use disorder measurement
0
5.8
32
hip circumference
1
28.4
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 13
VGNC:7746
743682
Macaque
solute carrier family 39 member 13
713420
Mouse
MGI:1915677
68427
Rat
RGD:1304695
295928
Dog
solute carrier family 39 member 13
475981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 13
Macaque
solute carrier family 39 member 13
Mouse
Rat
Dog
solute carrier family 39 member 13
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96H72-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Zinc homeostasis
WikiPathways
Zinc homeostasis
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
NRF2 pathway
Name
Explore in Pharos
Explore in Source
Zinc homeostasis
Zinc homeostasis
Nuclear Receptors Meta-Pathway
NRF2 pathway
Protein-Protein Interactions (62)
1 – 10 of 62
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
Score: 0.858
Data Source: STRINGDB
SLC30A5
Tbio
Family: Transporter
Novelty: 0.02432633
Score: 0.831
Data Source: STRINGDB
SLC30A4
Tbio
Family: Transporter
Novelty: 0.02209
Score: 0.818
Data Source: STRINGDB
SLC30A6
Tbio
Family: Transporter
Novelty: 0.06083299
Score: 0.81
Data Source: STRINGDB
SLC30A9
Tbio
Family: Transporter
Novelty: 0.07156604
Score: 0.801
Data Source: STRINGDB
SLC39A11
Tbio
Family: Transporter
Novelty: 0.09770302
Score: 0.794
Data Source: STRINGDB
SLC39A1
Tbio
Family: Transporter
Novelty: 0.00678191
Score: 0.788
Data Source: STRINGDB
SLC39A2
Tbio
Family: Transporter
Novelty: 0.01886854
Score: 0.786
Data Source: STRINGDB
SLC30A7
Tbio
Family: Transporter
Novelty: 0.02998245
Score: 0.766
Data Source: STRINGDB
SLC30A2
Tbio
Family: Transporter
Novelty: 0.01904868
Score: 0.754
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.39

PubMed score by year
PubTator Score  6.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: