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Tclin
MT-ND1
NADH-ubiquinone oxidoreductase chain 1

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361390
  • ENSP00000354687
  • ENSG00000198888

Symbol
  • MTND1
  • NADH1
  • ND1
  • MTND1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
VGNC:11717
807867
Macaque
NADH dehydrogenase subunit 1
2846627
Mouse
MGI:101787
17716
Rat
RGD:620555
26193
Dog
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
VGNC:53139
804476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Macaque
NADH dehydrogenase subunit 1
Mouse
Rat
Dog
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P03886-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Metabolism of RNA
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (190)
1 – 10 of 190
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999999047
p_ni: 9.53e-7
Score: 0.986
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999798202
p_ni: 0.000201798
Score: 0.995
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999221883
p_ni: 0.000777839
p_wrong: 2.78e-7
Score: 0.993
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.998390028
p_ni: 0.001609807
p_wrong: 1.65e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.997423296
p_ni: 0.002576659
p_wrong: 4.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
PMEL
Tbio
Novelty: 0.00116525
p_int: 0.993754958
p_ni: 0.005059289
p_wrong: 0.001185753
Data Source: BioPlex
BTN2A1
Tbio
Novelty: 0.02259329
p_int: 0.945943846
p_ni: 0.054050009
p_wrong: 0.000006145
Data Source: BioPlex
KLK8
Tchem
Family: Enzyme
Novelty: 0.00975023
p_int: 0.938411272
p_ni: 0.051343529
p_wrong: 0.010245198
Data Source: BioPlex
TACR1
Tclin
Family: GPCR
Novelty: 0.00062762
p_int: 0.927002777
p_ni: 0.042652916
p_wrong: 0.030344307
Data Source: BioPlex
VSIG4
Tbio
Novelty: 0.01671671
p_int: 0.926065344
p_ni: 0.032633791
p_wrong: 0.041300865
Data Source: BioPlex
Publication Statistics
PubMed Score  1145.00

PubMed score by year
PubTator Score  405.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer