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Tbio
MT-ATP6
ATP synthase subunit a

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
1
cellular component
0.95
small molecule perturbation
0.84
biological process
0.74
molecular function
0.6


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.46   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 958.46   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded ATP synthase membrane subunit 6
VGNC:11712
807859
Macaque
ATP synthase F0 subunit 6
2846629
Mouse
MGI:99927
17705
Rat
RGD:621239
26197
Dog
mitochondrially encoded ATP synthase membrane subunit 6
VGNC:53134
804488
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded ATP synthase membrane subunit 6
Macaque
ATP synthase F0 subunit 6
Mouse
Rat
Dog
mitochondrially encoded ATP synthase membrane subunit 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P00846-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Metabolism of RNA
Mitochondrial biogenesis
Protein-Protein Interactions (202)
1 – 10 of 202
ATP5PF
Tbio
Family: Enzyme
Novelty: 0.00585408
p_int: 0.986747611
p_ni: 0.013252381
p_wrong: 7e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
MT-ND4
Tclin
Family: Enzyme
Novelty: 0.00079935
Score: 0.999
Data Source: STRINGDB
MT-CO3
Tbio
Family: Enzyme
Novelty: 0.00253369
Score: 0.999
Data Source: STRINGDB
MT-ND1
Tclin
Family: Enzyme
Novelty: 0.00090183
Score: 0.999
Data Source: STRINGDB
MT-CYB
Tbio
Novelty: 0.00012093
Score: 0.999
Data Source: STRINGDB
MT-CO2
Tchem
Family: Enzyme
Novelty: 0.00073921
Score: 0.998
Data Source: STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.01052213
Score: 0.998
Data Source: STRINGDB
ATP5F1C
Tbio
Family: Enzyme
Novelty: 0.07666564
Score: 0.996
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
Score: 0.996
Data Source: STRINGDB
MT-CO1
Tchem
Family: Enzyme
Novelty: 0.00008262
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  958.46

PubMed score by year
PubTator Score  301.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer