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Tbio
WHRN
Whirlin

Protein Summary
Description
Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. This gene is thought to function in the organization and stabilization of sterocilia elongation and actin cystoskeletal assembly, based on studies of the related mouse gene. Mutations in this gene have been associated with autosomal recessive non-syndromic deafness and Usher Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265134
  • ENSP00000265134
  • ENSG00000095397
  • ENST00000362057
  • ENSP00000354623
  • ENST00000374057
  • ENSP00000363170
  • ENST00000374059
  • ENSP00000363172

Symbol
  • DFNB31
  • KIAA1526
  • WI
  • CIP98
  • USH2D
  • DFNB31
  • PDZD7B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
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GlyGen
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.63   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.63   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (59)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
3
3
3
74.9
energy expenditure
1
1
1
15.3
insulin sensitivity measurement
1
1
1
15.3
hip circumference
1
1
1
15.3
C-reactive protein measurement
1
1
1
15.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
3
74.9
energy expenditure
1
15.3
insulin sensitivity measurement
1
15.3
hip circumference
1
15.3
C-reactive protein measurement
1
15.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
whirlin
708051
Mouse
MGI:2682003
73750
Rat
RGD:631330
313255
Dog
whirlin
VGNC:48408
612588
Horse
whirlin
VGNC:25032
100051206
Species
Name
OMA
EggNOG
Inparanoid
Macaque
whirlin
Mouse
Rat
Dog
whirlin
Horse
whirlin
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (79)
1 – 10 of 79
MYO15A
Tbio
Novelty: 0.0148787
Score: 0.954
Data Source: STRINGDB
USH2A
Tbio
Novelty: 0.00223387
Score: 0.921
Data Source: STRINGDB
MYO7A
Tbio
Novelty: 0.00314435
Score: 0.899
Data Source: STRINGDB
ADGRV1
Tbio
Family: GPCR
Novelty: 0.01398129
Score: 0.876
Data Source: STRINGDB
USH1G
Tbio
Novelty: 0.02912203
Score: 0.873
Data Source: STRINGDB
PCDH15
Tbio
Novelty: 0.0097699
Score: 0.858
Data Source: STRINGDB
CDH23
Tbio
Novelty: 0.00588227
Score: 0.839
Data Source: STRINGDB
CLRN1
Tbio
Novelty: 0.03334995
Score: 0.835
Data Source: STRINGDB
LRRC4C
Tbio
Novelty: 0.06534005
Score: 0.809
Data Source: STRINGDB
EPS8
Tbio
Family: Enzyme
Novelty: 0.01023541
Score: 0.807
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.63

PubMed score by year
PubTator Score  27.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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