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Tclin
PTGS1
Prostaglandin G/H synthase 1

Protein Summary
Description
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tum ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223423
  • ENSP00000223423
  • ENSG00000095303
  • ENST00000362012
  • ENSP00000354612
  • ENST00000373698
  • ENSP00000362802
  • ENST00000540753
  • ENSP00000437709
  • ENST00000614910
  • ENSP00000484800

Symbol
  • COX1
  • COX1
  • COX3
  • PHS1
  • PCOX1
  • PES-1
  • PGHS1
  • PTGHS
  • PGG/HS
  • PGHS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
chemical
0.97
PubMedID
0.97
transcription factor perturbation
0.96
biological term
0.95


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2264.81   (req: < 5)
Gene RIFs: 188   (req: <= 3)
Antibodies: 627   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2264.81   (req: >= 5)
Gene RIFs: 188   (req: > 3)
Antibodies: 627   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 281
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 42
Approved Drugs (42)
1 – 10 of 42
celecoxib
chemical structure image
flufenamic acid
chemical structure image
indomethacin
chemical structure image
diclofenac
chemical structure image
mefenamic acid
chemical structure image
meclofenamic acid
chemical structure image
mesalazine
chemical structure image
ibuprofen
chemical structure image
sulindac
chemical structure image
tenidap
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin-endoperoxide synthase 1
VGNC:9192
464713
Macaque
prostaglandin-endoperoxide synthase 1
698213
Mouse
MGI:97797
19224
Rat
RGD:3439
24693
Dog
prostaglandin-endoperoxide synthase 1
VGNC:45151
403544
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin-endoperoxide synthase 1
Macaque
prostaglandin-endoperoxide synthase 1
Mouse
Rat
Dog
prostaglandin-endoperoxide synthase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P23219-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (33)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
COX reactions
Reactome
Fatty acid metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
COX reactions
Fatty acid metabolism
Metabolism
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (133)
1 – 10 of 133
PTGIS
Tchem
Family: Enzyme
Novelty: 0.00183292
Score: 0.981
Data Source: STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
Score: 0.973
Data Source: STRINGDB
PTGES
Tchem
Family: Enzyme
Novelty: 0.00146096
Score: 0.97
Data Source: STRINGDB
TBXAS1
Tchem
Family: Enzyme
Novelty: 0.0053649
Score: 0.965
Data Source: STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
Score: 0.958
Data Source: STRINGDB
ALOX15
Tchem
Family: Enzyme
Novelty: 0.00184734
Score: 0.958
Data Source: STRINGDB
ALOX12
Tchem
Family: Enzyme
Novelty: 0.00287761
Score: 0.958
Data Source: STRINGDB
PTGES3
Tbio
Family: Enzyme
Novelty: 0.0082783
Score: 0.957
Data Source: STRINGDB
PTGDS
Tchem
Family: Enzyme
Novelty: 0.002111
Score: 0.951
Data Source: STRINGDB
ALOX15B
Tchem
Family: Enzyme
Novelty: 0.01578108
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  2264.81

PubMed score by year
PubTator Score  1015.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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