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Tbio
MT-CYB
Cytochrome b

Protein Classes
Protein Summary
Description
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8514.25   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8514.25   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded cytochrome b
VGNC:11718
807858
Macaque
cytochrome b
2846625
Mouse
MGI:102501
17711
Rat
RGD:620081
26192
Dog
mitochondrially encoded cytochrome b
VGNC:53138
804486
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded cytochrome b
Macaque
cytochrome b
Mouse
Rat
Dog
mitochondrially encoded cytochrome b
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00156-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of RNA
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (259)
1 – 10 of 259
UQCRB
Tbio
Novelty: 0.02933046
p_int: 0.999977286
p_ni: 0.000022714
Score: 0.999
Data Source: BioPlex,STRINGDB
UQCRQ
Tbio
Novelty: 0.04392627
p_int: 0.999972982
p_ni: 0.000026836
p_wrong: 1.82e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
p_int: 0.999900327
p_ni: 0.000030095
p_wrong: 0.000069578
Data Source: BioPlex
UQCRH
Tbio
Novelty: 0.04494433
p_int: 0.995231092
p_ni: 0.000298684
p_wrong: 0.004470224
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.994702294
p_ni: 0.000506882
p_wrong: 0.004790823
Data Source: BioPlex
CLDND1
Tbio
Novelty: 0.06681793
p_int: 0.994435508
p_ni: 0.00021298
p_wrong: 0.005351513
Score: 0.189
Data Source: BioPlex,STRINGDB
MT-ND5
Tclin
Family: Enzyme
Novelty: 0.00223164
Score: 0.999
Data Source: STRINGDB
MT-CO3
Tbio
Family: Enzyme
Novelty: 0.00253369
Score: 0.999
Data Source: STRINGDB
MT-CO1
Tchem
Family: Enzyme
Novelty: 0.00008262
Score: 0.999
Data Source: STRINGDB
MT-ND2
Tclin
Family: Enzyme
Novelty: 0.00069255
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  8514.25

PubMed score by year
PubTator Score  2575.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer