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Tchem
MT-CO1
Cytochrome c oxidase subunit 1

Protein Summary
Description
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361624
  • ENSP00000354499
  • ENSG00000198804

Symbol
  • COI
  • COXI
  • MTCO1
  • COI
  • MTCO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12547.87   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12547.87   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded cytochrome c oxidase I
VGNC:11714
807866
Macaque
cytochrome c oxidase subunit I
2846624
Mouse
MGI:102504
17708
Rat
RGD:621871
26195
Dog
mitochondrially encoded cytochrome c oxidase I
VGNC:53136
804478
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrially encoded cytochrome c oxidase I
Macaque
cytochrome c oxidase subunit I
Mouse
Rat
Dog
mitochondrially encoded cytochrome c oxidase I
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P00395-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of RNA
RNA Polymerase II Transcription
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (209)
1 – 10 of 209
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00208873
p_int: 0.998243788
p_ni: 0.001756212
Score: 0.992
Data Source: BioPlex,STRINGDB
COX6A1
Tbio
Family: Enzyme
Novelty: 0.05543187
p_int: 0.994598157
p_ni: 0.005401843
Score: 0.983
Data Source: BioPlex,STRINGDB
RETREG3
Tdark
Novelty: 0.99215801
p_int: 0.994044696
p_ni: 0.005948286
p_wrong: 0.000007018
Data Source: BioPlex
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02212992
p_int: 0.994043833
p_ni: 0.005920244
p_wrong: 0.000035923
Data Source: BioPlex
TACR1
Tclin
Family: GPCR
Novelty: 0.00062762
p_int: 0.989197509
p_ni: 0.010802346
p_wrong: 1.44e-7
Data Source: BioPlex
OPRM1
Tclin
Family: GPCR
Novelty: 0.0003701
p_int: 0.976464629
p_ni: 0.023535364
p_wrong: 7e-9
Data Source: BioPlex
ASGR2
Tbio
Novelty: 0.14671716
p_int: 0.941955961
p_ni: 0.057811472
p_wrong: 0.000232567
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.932379092
p_ni: 0.06755252
p_wrong: 0.000068389
Data Source: BioPlex
P2RY12
Tclin
Family: GPCR
Novelty: 0.00035406
p_int: 0.893990988
p_ni: 0.10600901
p_wrong: 2e-9
Data Source: BioPlex
UXS1
Tbio
Family: Enzyme
Novelty: 0.04671281
p_int: 0.873440045
p_ni: 0.126474629
p_wrong: 0.000085326
Data Source: BioPlex
Publication Statistics
PubMed Score  12547.87

PubMed score by year
PubTator Score  4312.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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