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Tchem
STAT1
Signal transducer and activator of transcription 1-alpha/beta

Protein Classes
Protein Summary
Description
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361099
  • ENSP00000354394
  • ENSG00000115415
  • ENST00000392322
  • ENSP00000376136
  • ENST00000409465
  • ENSP00000386244

Symbol
  • CANDF7
  • IMD31A
  • IMD31B
  • IMD31C
  • ISGF-3
  • STAT91
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
interacting protein
1
kinase
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3001.44   (req: < 5)
Gene RIFs: 604   (req: <= 3)
Antibodies: 2120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3001.44   (req: >= 5)
Gene RIFs: 604   (req: > 3)
Antibodies: 2120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL297453
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
2
2
81
reticulocyte count
2
1
2
47.3
reticulocyte measurement
2
1
2
46.3
JT interval
1
1
0
4.1
16.9
response to sulfonylurea
1
1
0
4.1
16.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
2
81
reticulocyte count
2
47.3
reticulocyte measurement
2
46.3
JT interval
0
4.1
16.9
response to sulfonylurea
0
4.1
16.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal transducer and activator of transcription 1
VGNC:2869
459834
Macaque
signal transducer and activator of transcription 1
693650
Mouse
MGI:103063
20846
Horse
signal transducer and activator of transcription 1
VGNC:23663
100069633
Cow
signal transducer and activator of transcription 1, 91kDa
510814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal transducer and activator of transcription 1
Macaque
signal transducer and activator of transcription 1
Mouse
Horse
signal transducer and activator of transcription 1
Cow
signal transducer and activator of transcription 1, 91kDa
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P42224-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (210)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signal transduction
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signal transduction
Gene Ontology Terms (77)
Items per page:
10
1 – 10 of 20
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (581)
1 – 10 of 581
STAT2
Tbio
Family: TF
Novelty: 0.00241454
p_int: 1
Score: 0.971
Data Source: BioPlex,Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
p_int: 0.999892474
p_ni: 0.000107526
Score: 0.972
Data Source: BioPlex,Reactome,STRINGDB
DOCK4
Tbio
Novelty: 0.02356655
p_int: 0.996759289
p_ni: 0.003238479
p_wrong: 0.000002232
Score: 0.321
Data Source: BioPlex,STRINGDB
STAT4
Tbio
Family: TF
Novelty: 0.00251747
p_int: 0.988009607
p_ni: 0.011990393
Score: 0.945
Data Source: BioPlex,Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.998
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.997
Data Source: Reactome,STRINGDB
IRF9
Tbio
Family: TF
Novelty: 0.00751233
Score: 0.997
Data Source: Reactome,STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.996
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.995
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  3001.44

PubMed score by year
PubTator Score  1975.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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