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Tbio
LAMC3
Laminin subunit gamma-3

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric lamini ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361069
  • ENSP00000354360
  • ENSG00000050555

Symbol
  • OCCM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
kinase perturbation
0.71
gene perturbation
0.65
tissue sample
0.64
cell line
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.47   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.47   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
82.8
oral cavity cancer
1
1
0
1.3
31.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
82.8
oral cavity cancer
0
1.3
31.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1344394
23928
Rat
RGD:1309399
311862
Dog
laminin subunit gamma 3
VGNC:42573
491290
Horse
laminin subunit gamma 3
VGNC:19569
100069663
Opossum
laminin subunit gamma 3
100015877
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
laminin subunit gamma 3
Horse
laminin subunit gamma 3
Opossum
laminin subunit gamma 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6N6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Laminin interactions
Reactome
MET activates PTK2 signaling
Reactome
MET promotes cell motility
Reactome
Non-integrin membrane-ECM interactions
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Laminin interactions
MET activates PTK2 signaling
MET promotes cell motility
Non-integrin membrane-ECM interactions
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (87)
1 – 10 of 87
LAMA5
Tbio
Novelty: 0.02247145
Score: 0.989
Data Source: STRINGDB
LAMA3
Tbio
Novelty: 0.00733792
Score: 0.989
Data Source: STRINGDB
LAMB1
Tbio
Novelty: 0.0104285
Score: 0.982
Data Source: Reactome,STRINGDB
LAMB2
Tbio
Novelty: 0.07966931
Score: 0.98
Data Source: Reactome,STRINGDB
NID1
Tbio
Novelty: 0.00169075
Score: 0.974
Data Source: STRINGDB
NID2
Tbio
Novelty: 0.01638372
Score: 0.95
Data Source: STRINGDB
LAMB3
Tbio
Novelty: 0.00717673
Score: 0.94
Data Source: STRINGDB
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.939
Data Source: STRINGDB
NTN4
Tbio
Novelty: 0.03056042
Score: 0.938
Data Source: STRINGDB
LAMA1
Tbio
Novelty: 0.00852401
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.47

PubMed score by year
PubTator Score  9.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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