You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Protein Summary
Description
By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function. This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360971
  • ENSP00000354238
  • ENSG00000197594
  • ENST00000647893
  • ENSP00000498074

Symbol
  • M6S1
  • NPPS
  • PC1
  • PDNP1
  • M6S1
  • NPP1
  • NPPS
  • PC-1
  • PCA1
  • ARHR2
  • COLED
  • PDNP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
protein domain
0.99
transcription factor perturbation
0.97
gene perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.68   (req: < 5)
Gene RIFs: 163   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.68   (req: >= 5)
Gene RIFs: 163   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B2 (riboflavin) metabolism
Reactome
Vitamin B5 (pantothenate) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B2 (riboflavin) metabolism
Vitamin B5 (pantothenate) metabolism
Gene Ontology Terms (41)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred by Curator (IC)
BHF-UCL
Protein-Protein Interactions (245)
1 – 10 of 245
PTCH1
Tbio
Novelty: 0.00077635
p_int: 0.967821785
p_ni: 0.032178215
Data Source: BioPlex
BZW1
Tbio
Novelty: 0.11677238
p_int: 0.961798207
p_ni: 0.038201793
Score: 0.256
Data Source: BioPlex,STRINGDB
FANCE
Tbio
Novelty: 0.04484113
p_int: 0.953626917
p_ni: 0.046373083
p_wrong: 1e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
FNTB
Tchem
Family: Enzyme
Novelty: 0.07434994
p_int: 0.928774283
p_ni: 0.071225717
Score: 0.158
Data Source: BioPlex,STRINGDB
LCN6
Tbio
Novelty: 0.11406686
p_int: 0.853946293
p_ni: 0.146053707
Data Source: BioPlex
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
p_int: 0.807306548
p_ni: 0.192693452
Score: 0.157
Data Source: BioPlex,STRINGDB
PON2
Tbio
Family: Enzyme
Novelty: 0.00414855
p_int: 0.777103072
p_ni: 0.222896928
Data Source: BioPlex
EIF2B2
Tbio
Novelty: 0.03253919
p_int: 0.76285962
p_ni: 0.23714038
Score: 0.217
Data Source: BioPlex,STRINGDB
ALPL
Tchem
Family: Enzyme
Novelty: 0.00152281
Score: 0.973
Data Source: STRINGDB
ENTPD3
Tbio
Family: Enzyme
Novelty: 0.01673548
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  426.68

PubMed score by year
PubTator Score  329.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: