Tclin TLR9 Toll-like receptor 9

Protein Summary

Description

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• Q9NR96
• B3Y661
• D1CS56
• Q6UVZ2
• Q9HD68
• Q9HD69
• Q9HD70
• Q9NYC2
• Q9NYC3

Gene Name

• TLR9

Ensembl ID

• ENST00000360658
• ENSP00000353874
• ENSG00000239732

Symbol

• CD289

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
cellular component	0.99
disease	0.82
phenotype	0.82

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1188.02   (req: < 5)

Gene RIFs: 577   (req: <= 3)

Antibodies: 971   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1188.02   (req: >= 5)

Gene RIFs: 577   (req: > 3)

Antibodies: 971   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

hydroxychloroquine

TLR9Tclin

ANTAGONIST IC50: 7.1

Active Ligands (40)

Explore Active Ligands

1 – 10 of 40

CHEMBL3898735

TLR9Tclin

IC50: 6.31

CHEMBL3357064

TLR9Tclin

IC50: 8.07

CHEMBL3966000

TLR9Tclin

IC50: 6.91

CHEMBL3357070

TLR9Tclin

IC50: 7.89

CHEMBL3356618

TLR9Tclin

IC50: 8.46

CHEMBL3357069

TLR9Tclin

IC50: 7.55

CHEMBL3932650

TLR9Tclin

IC50: 6.04

CHEMBL3357063

TLR9Tclin

IC50: 7.14

CHEMBL3357062

TLR9Tclin

IC50: 8.41

CHEMBL3357067

TLR9Tclin

IC50: 7.25

Pathways (256)

Reactome (22)

KEGG (8)

PathwayCommons (1)

WikiPathways (225)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:

5

1 – 5 of 22

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	FLT3 Signaling	264 targets	R-HSA-9607240
Reactome	IGF1R signaling cascade	53 targets	R-HSA-2428924
Reactome	IRS-mediated signalling	48 targets	R-HSA-112399
Reactome	IRS-related events triggered by IGF1R	52 targets	R-HSA-2428928

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
FLT3 Signaling	264 targets	R-HSA-9607240
IGF1R signaling cascade	53 targets	R-HSA-2428924
IRS-mediated signalling	48 targets	R-HSA-112399
IRS-related events triggered by IGF1R	52 targets	R-HSA-2428928

Gene Ontology Terms (70)

Functions (7)

Components (14)

Processes (49)

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
interleukin-1 receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
siRNA binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
signaling pattern recognition receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein homodimerization activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
unmethylated CpG binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
1-phosphatidylinositol-3-kinase activity	Traceable Author Statement (TAS)	Reactome
transmembrane signaling receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (244)

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1 – 10 of 244

• See Interactions on String-DB

MYD88

Tbio

Novelty: 0.00054413

Score: 0.993

Data Source: Reactome,STRINGDB

IL10

Tbio

Novelty: 0.00007359

Score: 0.883

Data Source: STRINGDB

IL6

Tclin

Novelty: 0.00002829

Score: 0.876

Data Source: STRINGDB

CD40

Tchem

Novelty: 0.0003399

Score: 0.855

Data Source: STRINGDB

UNC93B1

Tbio

Novelty: 0.01966959

Score: 0.836

Data Source: Reactome,STRINGDB

TLR7

Tclin

Novelty: 0.00059474

Score: 0.835

Data Source: Reactome,STRINGDB

CAMP

Tbio

Novelty: 0.00089449

Score: 0.833

Data Source: STRINGDB

TNF

Tclin

Novelty: 0.00001974

Score: 0.798

Data Source: STRINGDB

CXCL8

Tchem

Novelty: 0.00009183

Score: 0.794

Data Source: STRINGDB

FOXP3

Tbio

Family: TF

Novelty: 0.00020363

Score: 0.793

Data Source: STRINGDB

Publication Statistics

PubMed Score  1188.02

PubMed score by year

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PubTator Score  1581.06

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSL

1-70

SSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPA

70-140

LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNN

140-210

LTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTF

210-280

SHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVS

280-350

FAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV

350-420

DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPE

420-490

MFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFG

490-560

MQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGL

560-630

IWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAG

630-700

TRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAF

700-770

MDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG

770-840

WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEE

840-910

RDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRY

910-980

VRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE

980-1032

MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE

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Uniprot Keyword

Alternative splicing
Complete proteome
Cytoplasmic vesicle
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Immunity
Inflammatory response
Innate immunity