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Tbio
DSC3
Desmocollin-3

Protein Summary
Description
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for so ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360428
  • ENSP00000353608
  • ENSG00000134762
  • ENST00000434452
  • ENSP00000392068

Symbol
  • CDHF3
  • DSC4
  • DSC
  • DSC1
  • DSC2
  • DSC4
  • CDHF3
  • HT-CP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
virus perturbation
0.83
microRNA
0.7
cell type or tissue
0.69
gene perturbation
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.21   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.21   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (77)
1 – 10 of 77
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.900027602
p_ni: 0.099972398
Score: 0.206
Data Source: BioPlex,STRINGDB
PKP3
Tbio
Novelty: 0.0269462
Score: 0.99
Data Source: STRINGDB
PKP2
Tbio
Novelty: 0.00493803
Score: 0.989
Data Source: STRINGDB
DSP
Tbio
Novelty: 0.00178018
Score: 0.988
Data Source: STRINGDB
PKP1
Tbio
Novelty: 0.0100609
Score: 0.988
Data Source: STRINGDB
JUP
Tbio
Novelty: 0.0081803
Score: 0.985
Data Source: STRINGDB
PKP4
Tbio
Novelty: 0.03654703
Score: 0.968
Data Source: STRINGDB
EVPL
Tbio
Novelty: 0.00274279
Score: 0.95
Data Source: STRINGDB
PERP
Tbio
Novelty: 0.00773799
Score: 0.95
Data Source: STRINGDB
PPL
Tbio
Novelty: 0.00684645
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  224.21

PubMed score by year
PubTator Score  276.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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