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Tbio
PARP9
Poly [ADP-ribose] polymerase 9

Protein Summary
Description
ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360356
  • ENSP00000353512
  • ENSG00000138496
  • ENST00000462315
  • ENSP00000418894
  • ENST00000471785
  • ENSP00000419001
  • ENST00000477522
  • ENSP00000419506

Symbol
  • BAL
  • BAL1
  • BAL
  • BAL1
  • ARTD9
  • MGC:7868
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.83
transcription factor perturbation
0.8
tissue sample
0.74
PubMedID
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.84   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.84   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
27.9
total cholesterol measurement
1
1
1
15.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
27.9
total cholesterol measurement
1
15.6
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinamide salvaging
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinamide salvaging
Nicotinate metabolism
Gene Ontology Terms (34)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (91)
1 – 10 of 91
DTX3L
Tbio
Family: Enzyme
Novelty: 0.0622833
p_int: 1
Score: 0.996
Data Source: BioPlex,STRINGDB
PARP14
Tbio
Family: Enzyme
Novelty: 0.01791617
Score: 0.963
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.93
Data Source: STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.922
Data Source: STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.91
Data Source: STRINGDB
PARP12
Tbio
Family: Enzyme
Novelty: 0.08076657
Score: 0.907
Data Source: STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.907
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.832
Data Source: STRINGDB
USP18
Tbio
Family: Enzyme
Novelty: 0.01087689
Score: 0.785
Data Source: STRINGDB
IFI44
Tbio
Novelty: 0.02787222
Score: 0.781
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.84

PubMed score by year
PubTator Score  207.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer