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Tbio
MSN
Moesin

Protein Summary
Description
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666). Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360270
  • ENSP00000353408
  • ENSG00000147065

Symbol
  • HEL70
  • IMD50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
interacting protein
0.97
kinase
0.95
kinase perturbation
0.93
biological term
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 453.36   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 925   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 453.36   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 925   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
1
1
24.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
24.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
moesin
711712
Mouse
MGI:97167
17698
Rat
RGD:621260
81521
Dog
moesin
VGNC:43447
491924
Horse
moesin
VGNC:20392
100065348
Species
Name
OMA
EggNOG
Inparanoid
Macaque
moesin
Mouse
Rat
Dog
moesin
Horse
moesin
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26038-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Gene Ontology Terms (51)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (202)
1 – 10 of 202
EZR
Tbio
Novelty: 0.00115353
p_int: 0.999650763
p_ni: 0.000349237
Score: 0.948
Data Source: BioPlex,STRINGDB
MISP
Tbio
Novelty: 0.02030151
p_int: 0.952895386
p_ni: 0.047104614
Score: 0.257
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.884496675
p_ni: 0.115503325
Data Source: BioPlex
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.827004592
p_ni: 0.172995408
Data Source: BioPlex
TSPAN33
Tbio
Novelty: 0.17463296
p_int: 0.755716712
p_ni: 0.244283288
Score: 0.58
Data Source: BioPlex,STRINGDB
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.00357766
Score: 0.995
Data Source: STRINGDB
ROCK2
Tclin
Family: Kinase
Novelty: 0.00242311
Score: 0.976
Data Source: STRINGDB
ROCK1
Tclin
Family: Kinase
Novelty: 0.00156045
Score: 0.974
Data Source: STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.954
Data Source: STRINGDB
L1CAM
Tbio
Novelty: 0.00307041
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  453.36

PubMed score by year
PubTator Score  963.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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