Tbio MAGEA4 Melanoma-associated antigen 4

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Melanoma-associated Antigen 4

Protein Summary

Description

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43358
• Q14798

Gene Name

• MAGEA4

Ensembl ID

• ENST00000276344
• ENSP00000276344
• ENSG00000147381
• ENST00000360243
• ENSP00000353379
• ENST00000370335
• ENSP00000359360
• ENST00000370340
• ENSP00000359365
• ENST00000393920
• ENSP00000377497
• ENST00000393921
• ENSP00000377498

Symbol

• MAGE4
• CT1.4
• MAGE4
• MAGE4A
• MAGE4B
• MAGE-41
• MAGE-X2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.83
transcription factor	0.51
biological term	0.48
cell line	0.48
microRNA	0.47

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.45   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 327   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.45   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Protein-Protein Interactions (84)

Explore Interacting Targets

1 – 10 of 84

• See Interactions on String-DB

MAGEA10

Tbio

Novelty: 0.0518709

p_int: 0.999999999

p_wrong: 1e-9

Score: 0.599

Data Source: BioPlex,STRINGDB

TSPYL4

Tdark

Novelty: 0.64864865

p_int: 0.999999796

p_ni: 1.87e-7

p_wrong: 1.6e-8

Score: 0.663

Data Source: BioPlex,STRINGDB

PPP1R13L

Tbio

Novelty: 0.01551275

p_int: 0.999999726

p_ni: 2.74e-7

Score: 0.189

Data Source: BioPlex,STRINGDB

MAGEA9

Tbio

Novelty: 0.05648387

p_int: 0.999999603

p_ni: 4e-9

p_wrong: 3.93e-7

Data Source: BioPlex

MAGEB16

Tdark

Novelty: 0.26373626

p_int: 0.999998916

p_wrong: 0.000001084

Score: 0.294

Data Source: BioPlex,STRINGDB

MDM1

Tbio

Novelty: 0.05983444

p_int: 0.999998849

p_ni: 2.9e-8

p_wrong: 0.000001122

Score: 0.261

Data Source: BioPlex,STRINGDB

RAD18

Tbio

Family: Enzyme

Novelty: 0.00575302

p_int: 0.999994381

p_ni: 0.000005619

Score: 0.305

Data Source: BioPlex,STRINGDB

UQCRB

Tbio

Novelty: 0.04413786

p_int: 0.999930193

p_ni: 0.000069807

Score: 0.234

Data Source: BioPlex,STRINGDB

TIGD5

Tdark

Novelty: 2.52631579

p_int: 0.99975571

p_ni: 0.00024429

Score: 0.224

Data Source: BioPlex,STRINGDB

CCDC85B

Tdark

Novelty: 0.01424139

p_int: 0.999308648

p_ni: 0.000689105

p_wrong: 0.000002247

Score: 0.177

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  108.45

PubMed score by year

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PubTator Score  120.22

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGAS

1-70

ALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERV

70-140

IKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTI

140-210

AMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALA

210-280

ETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV

280-317

MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV

Find similar targets by:

Uniprot Keyword

3D-structure
Complete proteome
Polymorphism
Reference proteome
Tumor antigen