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Tchem
CACNA1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360228
  • ENSP00000353362
  • ENSG00000141837
  • ENST00000637276
  • ENSP00000489777
  • ENST00000637432
  • ENSP00000490617
  • ENST00000638009
  • ENSP00000489913

Symbol
  • CACH4
  • CACN3
  • CACNL1A4
  • BI
  • EA2
  • FHM
  • MHP
  • APCA
  • HPCA
  • MHP1
  • SCA6
  • CAV2.1
  • EIEE42
  • CACNL1A4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.93
molecular function
0.93
cellular component
0.84
phenotype
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1455.71   (req: < 5)
Gene RIFs: 171   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1455.71   (req: >= 5)
Gene RIFs: 171   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
mibefradil
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
77.8
depressive symptom measurement
1
1
1
43.6
wellbeing measurement
1
1
1
43.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
77.8
depressive symptom measurement
1
43.6
wellbeing measurement
1
43.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 A
VGNC:10912
455766
Macaque
calcium voltage-gated channel subunit alpha1 A
718291
Mouse
MGI:109482
12286
Rat
RGD:2244
25398
Dog
calcium voltage-gated channel subunit alpha1 A
VGNC:38631
100686650
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 A
Macaque
calcium voltage-gated channel subunit alpha1 A
Mouse
Rat
Dog
calcium voltage-gated channel subunit alpha1 A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00555-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Integration of energy metabolism (R-HSA-163685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Neuronal System
Reactome
Presynaptic depolarization and calcium channel opening
Reactome
Regulation of insulin secretion
Name
Explore in Pharos
Explore in Source
Integration of energy metabolism
Metabolism
Neuronal System
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (232)
1 – 10 of 232
FSCN1
Tbio
Novelty: 0.00221877
p_int: 0.999425584
p_ni: 5.6e-8
p_wrong: 0.000574361
Data Source: BioPlex
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
Score: 0.991
Data Source: Reactome,STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.981
Data Source: STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
Score: 0.978
Data Source: STRINGDB
CACNA2D2
Tclin
Family: IC
Novelty: 0.02041017
Score: 0.974
Data Source: Reactome,STRINGDB
CACNA2D3
Tbio
Family: IC
Novelty: 0.05267262
Score: 0.968
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.947
Data Source: STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.00808502
Score: 0.946
Data Source: Reactome,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.926
Data Source: STRINGDB
PRKCG
Tchem
Family: Kinase
Novelty: 0.00291817
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  1455.71

PubMed score by year
PubTator Score  1068.69

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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