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Tbio
SPN
Leukosialin

Protein Summary
Description
Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360121
  • ENSP00000353238
  • ENSG00000197471
  • ENST00000395389
  • ENSP00000378787
  • ENST00000563039
  • ENSP00000455266

Symbol
  • CD43
  • LSN
  • CD43
  • GALGP
  • GPL115
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.76
transcription factor
0.74
small molecule perturbation
0.7
cell type or tissue
0.65
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 779.92   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 2013   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 779.92   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 2013   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cell surface interactions at the vascular wall
Hemostasis
Protein-Protein Interactions (174)
1 – 10 of 174
EIF2B3
Tbio
Novelty: 0.04963646
p_int: 0.870528449
p_ni: 0.129471551
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC39A11
Tbio
Family: Transporter
Novelty: 0.09770302
p_int: 0.769156735
p_ni: 0.230843096
p_wrong: 1.7e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
SPAG9
Tbio
Family: Enzyme
Novelty: 0.00527315
p_int: 0.759229447
p_ni: 0.240770553
Score: 0.189
Data Source: BioPlex,STRINGDB
SELE
Tchem
Novelty: 0.00029494
Score: 0.968
Data Source: Reactome,STRINGDB
BSG
Tbio
Novelty: 0.0010285
Score: 0.952
Data Source: Reactome,STRINGDB
SIGLEC1
Tbio
Novelty: 0.00369952
Score: 0.937
Data Source: STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00012027
Score: 0.88
Data Source: STRINGDB
CD5
Tbio
Novelty: 0.00032883
Score: 0.877
Data Source: STRINGDB
CD19
Tclin
Novelty: 0.0001816
Score: 0.834
Data Source: STRINGDB
MSN
Tbio
Novelty: 0.00178275
Score: 0.833
Data Source: STRINGDB
Publication Statistics
PubMed Score  779.92

PubMed score by year
PubTator Score  376.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer