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Tbio
TEAD4
Transcriptional enhancer factor TEF-3

Protein Summary
Description
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and bind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397122
  • ENSP00000380311
  • ENSG00000197905

Symbol
  • RTEF1
  • TCF13L1
  • TEF3
  • TEF3
  • RTEF1
  • TEF-3
  • EFTR-2
  • TEFR-1
  • TCF13L1
  • hRTEF-1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
transcription factor perturbation
0.84
disease perturbation
0.83
transcription factor binding site profile
0.73
cell type or tissue
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.84   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.84   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
47.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
47.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TEA domain transcription factor 4
VGNC:5617
451756
Mouse
MGI:106907
21679
Rat
RGD:1585671
683522
Dog
TEA domain transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11717]
Horse
TEA domain transcription factor 4
VGNC:23981
100057619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TEA domain transcription factor 4
Mouse
Rat
Dog
TEA domain transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11717]
Horse
TEA domain transcription factor 4
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15561-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX3 regulates YAP1-mediated transcription
Reactome
Transcriptional regulation by RUNX3
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX3 regulates YAP1-mediated transcription
Transcriptional regulation by RUNX3
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (85)
1 – 10 of 85
WWTR1
Tbio
Novelty: 0.00431186
p_int: 1
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
TEAD2
Tbio
Family: TF
Novelty: 0.02487024
p_int: 1
Score: 0.984
Data Source: BioPlex,STRINGDB
VGLL4
Tbio
Novelty: 0.03384856
p_int: 1
Score: 0.903
Data Source: BioPlex,STRINGDB
TEAD1
Tbio
Family: TF
Novelty: 0.01198524
p_int: 0.999999997
p_ni: 3e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
YAP1
Tbio
Novelty: 0.00124225
p_int: 0.999999906
p_ni: 9.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
p_int: 0.999999742
p_ni: 2.58e-7
Score: 0.263
Data Source: BioPlex,STRINGDB
VASP
Tbio
Novelty: 0.00041984
p_int: 0.999984492
p_ni: 0.000015508
Score: 0.173
Data Source: BioPlex,STRINGDB
PARN
Tbio
Family: Enzyme
Novelty: 0.00738516
p_int: 0.996919166
p_ni: 0.003080758
p_wrong: 7.5e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
LYPLA1
Tchem
Family: Enzyme
Novelty: 0.01217068
p_int: 0.994353418
p_ni: 0.005630099
p_wrong: 0.000016482
Score: 0.228
Data Source: BioPlex,STRINGDB
VTA1
Tbio
Novelty: 0.01697854
p_int: 0.900312858
p_ni: 0.099687142
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  93.84

PubMed score by year
PubTator Score  31.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer