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Tbio
PCNT
Pericentrin

Protein Summary
Description
Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359568
  • ENSP00000352572
  • ENSG00000160299

Symbol
  • KIAA0402
  • PCNT2
  • KEN
  • PCN
  • MOPD2
  • PCNT2
  • PCNTB
  • PCTN2
  • SCKL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
histone modification site profile
0.85
cellular component
0.84
transcription factor binding site profile
0.75
interacting protein
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.57   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.57   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
69.1
viral load
1
1
1
59.9
HIV-1 infection
1
1
1
59.9
1
1
1
52.3
1
1
0
1.1
51.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
69.1
viral load
1
59.9
HIV-1 infection
1
59.9
1
52.3
0
1.1
51.6
Pathways (19)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (274)
1 – 10 of 274
LPXN
Tbio
Novelty: 0.00796678
p_int: 0.999998421
p_ni: 0.000001579
Data Source: BioPlex
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999993355
p_ni: 0.000006645
Data Source: BioPlex
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.999992105
p_ni: 0.000007895
Data Source: BioPlex
FAM81B
Tdark
Novelty: 2.38747104
p_int: 0.999975195
p_ni: 0.000024805
Score: 0.206
Data Source: BioPlex,STRINGDB
CTAG2
Tbio
Novelty: 0.02983879
p_int: 0.999959888
p_ni: 0.000040112
Score: 0.435
Data Source: BioPlex,STRINGDB
MZT1
Tdark
Novelty: 0.06713659
p_int: 0.999939463
p_ni: 0.000060537
Score: 0.948
Data Source: BioPlex,STRINGDB
FGL2
Tbio
Novelty: 0.01108434
p_int: 0.999854533
p_ni: 0.000145467
Score: 0.187
Data Source: BioPlex,STRINGDB
BIRC7
Tchem
Novelty: 0.00420245
p_int: 0.999796075
p_ni: 0.000203925
Score: 0.195
Data Source: BioPlex,STRINGDB
MIS18A
Tbio
Novelty: 0.08143008
p_int: 0.999646522
p_ni: 0.000353478
Data Source: BioPlex
C1orf87
Tbio
Novelty: 0.03162594
p_int: 0.999558571
p_ni: 0.000441429
Score: 0.186
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  256.57

PubMed score by year
PubTator Score  410.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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