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Tbio
EMP2
Epithelial membrane protein 2

Protein Summary
Description
Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359543
  • ENSP00000352540
  • ENSG00000213853
  • ENST00000536829
  • ENSP00000445712

Symbol
  • XMP
  • XMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
biological process
0.93
PubMedID
0.9
disease perturbation
0.87
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.06   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.06   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
41.8
heel bone mineral density
1
1
1
23.6
FEV/FEC ratio
1
1
1
4.7
1
1
0
1.1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
41.8
heel bone mineral density
1
23.6
FEV/FEC ratio
1
4.7
0
1.1
1.9
Gene Ontology Terms (40)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (59)
1 – 10 of 59
IMPDH2
Tclin
Family: Enzyme
Novelty: 0.00815361
Score: 0.796
Data Source: STRINGDB
IMPDH1
Tclin
Family: Enzyme
Novelty: 0.00758575
Score: 0.79
Data Source: STRINGDB
LITAF
Tbio
Family: TF
Novelty: 0.0097203
Score: 0.751
Data Source: STRINGDB
GMPS
Tbio
Family: Enzyme
Novelty: 0.00611806
Score: 0.678
Data Source: STRINGDB
TSPAN4
Tbio
Novelty: 0.03394894
Score: 0.669
Data Source: STRINGDB
UBTFL1
Tdark
Family: TF
Novelty: 0.60042165
Score: 0.655
Data Source: STRINGDB
SGO1
Tbio
Novelty: 0.01115849
Score: 0.638
Data Source: STRINGDB
FBXO16
Tdark
Novelty: 0.60353147
Score: 0.631
Data Source: STRINGDB
DAB2
Tbio
Novelty: 0.00534123
Score: 0.626
Data Source: STRINGDB
LPAR6
Tchem
Family: GPCR
Novelty: 0.01801122
Score: 0.623
Data Source: STRINGDB
Publication Statistics
PubMed Score  79.06

PubMed score by year
PubTator Score  40.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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