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Tbio
TCF20
Transcription factor 20

Protein Summary
Description
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335626
  • ENSP00000335561
  • ENSG00000100207
  • ENST00000359486
  • ENSP00000352463
  • ENST00000574943
  • ENSP00000460328
  • ENSG00000262024
  • ENST00000576946
  • ENSP00000460587
  • ENST00000619505
  • ENSP00000478503
  • ENSG00000276461
  • ENST00000621408
  • ENSP00000483199
  • ENST00000626486
  • ENSP00000487465
  • ENSG00000280467
  • ENST00000626726
  • ENSP00000487302
  • ENSG00000281897
  • ENST00000628774
  • ENSP00000487296
  • ENST00000629538
  • ENSP00000486940
  • ENST00000634489
  • ENSP00000489099
  • ENSG00000282892
  • ENST00000634616
  • ENSP00000489614
  • ENSG00000283026
  • ENST00000635146
  • ENSP00000489215
  • ENST00000635421
  • ENSP00000489006
  • ENST00000636799
  • ENSP00000490305
  • ENSG00000283681
  • ENST00000637355
  • ENSP00000489734

Symbol
  • KIAA0292
  • SPBP
  • AR1
  • SPBP
  • TCF-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
disease perturbation
0.95
kinase perturbation
0.95
ligand (protein) perturbation
0.83
tissue sample
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1108.61   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1108.61   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (72)
Items per page:
1 – 5 of 72
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
2
3
88.3
cognitive function measurement
3
2
3
88.3
cognitive function measurement
3
2
3
88.3
cognitive function measurement
3
2
3
88.3
cognitive function measurement
3
2
3
88.3
Items per page:
1 – 5 of 72
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
88.3
cognitive function measurement
3
88.3
cognitive function measurement
3
88.3
cognitive function measurement
3
88.3
cognitive function measurement
3
88.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transcription factor 20
710016
Mouse
MGI:108399
21411
Rat
RGD:1594486
366964
Dog
transcription factor 20
VGNC:47192
481224
Horse
transcription factor 20
VGNC:23949
100056129
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transcription factor 20
Mouse
Rat
Dog
transcription factor 20
Horse
transcription factor 20
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGU0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
FKBP9
Tbio
Family: Enzyme
Novelty: 0.16472204
p_int: 0.99999559
p_ni: 0.00000441
Score: 0.402
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.999988044
p_ni: 0.000011955
p_wrong: 1e-9
Score: 0.312
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.99805179
p_ni: 0.001936952
p_wrong: 0.000011258
Score: 0.244
Data Source: BioPlex,STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.859
Data Source: STRINGDB
MDC1
Tbio
Novelty: 0.00533097
Score: 0.717
Data Source: STRINGDB
QRICH1
Tdark
Novelty: 0.27714699
Score: 0.713
Data Source: STRINGDB
RAI1
Tbio
Family: Epigenetic
Novelty: 0.01088494
Score: 0.682
Data Source: STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
Score: 0.658
Data Source: STRINGDB
TOPBP1
Tbio
Family: Enzyme
Novelty: 0.00735579
Score: 0.657
Data Source: STRINGDB
HARS
Tchem
Family: Enzyme
Novelty: 0.01271582
Score: 0.635
Data Source: STRINGDB
Publication Statistics
PubMed Score  1108.61

PubMed score by year
PubTator Score  143.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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