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Tbio
FGF17
Fibroblast growth factor 17

Protein Summary
Description
Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359441
  • ENSP00000352414
  • ENSG00000158815
  • ENST00000518533
  • ENSP00000431041

Symbol
  • HH20
  • FGF-13
  • FGF-17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
cell type or tissue
0.69
PubMedID
0.65
protein domain
0.58
pathway
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.74   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.74   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 17
VGNC:12011
472708
Mouse
MGI:1202401
14171
Rat
RGD:2607
29368
Dog
fibroblast growth factor 17
VGNC:40844
607952
Horse
fibroblast growth factor 17
VGNC:18014
100056444
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 17
Mouse
Rat
Dog
fibroblast growth factor 17
Horse
fibroblast growth factor 17
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60258-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (97)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 74
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (126)
1 – 10 of 126
ANKHD1
Tbio
Novelty: 0.05390096
p_int: 0.999960077
p_ni: 0.000039923
Data Source: BioPlex
YBX2
Tbio
Family: TF
Novelty: 0.01540247
p_int: 0.999860548
p_ni: 0.000139451
Data Source: BioPlex
ANKRD17
Tbio
Novelty: 0.03177323
p_int: 0.991692989
p_ni: 0.008307011
Data Source: BioPlex
RPL36AL
Tbio
Novelty: 0.09336423
p_int: 0.978897293
p_ni: 0.020801646
p_wrong: 0.000301061
Data Source: BioPlex
DDX24
Tbio
Family: Enzyme
Novelty: 0.17803446
p_int: 0.959539614
p_ni: 0.040460386
Data Source: BioPlex
ZNF629
Tdark
Family: TF
Novelty: 0.00907269
p_int: 0.945809912
p_ni: 0.054190088
Data Source: BioPlex
RPS3
Tbio
Novelty: 0.003106
p_int: 0.944671842
p_ni: 0.055328158
Data Source: BioPlex
LRP2
Tbio
Novelty: 0.00143258
p_int: 0.938476678
p_ni: 0.061523322
Data Source: BioPlex
LARP1B
Tdark
Novelty: 0.22215724
p_int: 0.93143555
p_ni: 0.06856445
Data Source: BioPlex
RPL26L1
Tdark
Novelty: 0.75408617
p_int: 0.927865894
p_ni: 0.072134106
Data Source: BioPlex
Publication Statistics
PubMed Score  61.74

PubMed score by year
PubTator Score  13.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer