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Tbio
HIST1H3A
Histone H3.1

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the hi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356476
  • ENSP00000366999
  • ENSG00000197409
  • ENST00000359303
  • ENSP00000352252
  • ENSG00000197153
  • ENST00000369163
  • ENSP00000358160
  • ENSG00000278828
  • ENST00000612966
  • ENSP00000484658
  • ENSG00000278272
  • ENST00000613854
  • ENSP00000480826
  • ENSG00000275714
  • ENST00000614378
  • ENSP00000484638
  • ENSG00000273983
  • ENST00000614911
  • ENSP00000482271
  • ENSG00000274750
  • ENST00000616365
  • ENSP00000483283
  • ENSG00000275379
  • ENST00000618052
  • ENSP00000484095
  • ENSG00000277775
  • ENST00000621411
  • ENSP00000484841
  • ENSG00000274267
  • ENST00000634733
  • ENSP00000489282

Symbol
  • H3FA
  • H3/A
  • H3FA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
cellular component
0.7
histone modification site profile
0.7
gene perturbation
0.68
transcription factor
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 1676   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 1676   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (206 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P68431-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 206
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (73)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 67
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (25)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (224)
1 – 10 of 224
UBR7
Tbio
Family: Epigenetic
Novelty: 0.23270052
p_int: 0.999999972
p_ni: 2.8e-8
Data Source: BioPlex
CHAF1A
Tbio
Novelty: 0.02129179
p_int: 0.999999405
p_ni: 5.95e-7
Score: 0.458
Data Source: BioPlex,STRINGDB
TONSL
Tbio
Novelty: 0.07220129
p_int: 0.999989579
p_ni: 0.000010422
Data Source: BioPlex
MMS22L
Tbio
Novelty: 0.22570578
p_int: 0.999594935
p_ni: 0.000405064
p_wrong: 2e-9
Score: 0.249
Data Source: BioPlex,STRINGDB
MTA3
Tbio
Family: TF
Novelty: 0.02667635
p_int: 0.999585301
p_ni: 0.000414699
p_wrong: 1e-9
Data Source: BioPlex
FBLIM1
Tbio
Novelty: 0.0332985
p_int: 0.99935685
p_ni: 0.00042158
p_wrong: 0.000221571
Data Source: BioPlex
NASP
Tbio
Novelty: 0.00902599
p_int: 0.999299658
p_ni: 0.000700342
Score: 0.573
Data Source: BioPlex,STRINGDB
MTA1
Tbio
Family: TF
Novelty: 0.00464618
p_int: 0.999036294
p_ni: 0.000963706
Data Source: BioPlex
UHRF1
Tbio
Family: Epigenetic
Novelty: 0.00482565
p_int: 0.998842584
p_ni: 0.001157416
Score: 0.862
Data Source: BioPlex,Reactome,STRINGDB
SUPT16H
Tbio
Family: Enzyme
Novelty: 0.01026868
p_int: 0.998783508
p_ni: 0.001216493
Score: 0.787
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.39

PubMed score by year
PubTator Score  18.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer