Tbio SLC2A10 Solute carrier family 2, facilitated glucose transporter member 10

Protein Classes

PANTHER Classes

Protein / ... / Carbohydrate Transporter / Solute Carrier Family 2, Facilitated Glucose Transporter Member 10

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc2 Family Of Hexose And Sugar Alcohol Transporters / Class Ii Transporters / Solute Carrier Family 2, Facilitated Glucose Transporter Member 10

Protein Summary

Description

Facilitative glucose transporter. This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• O95528
• A8K4J6
• Q3MIX5
• Q9H4I6

Gene Name

• SLC2A10

Ensembl ID

• ENST00000359271
• ENSP00000352216
• ENSG00000197496

Symbol

• GLUT10
• ATS
• ATORS
• GLUT10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.8
tissue sample	0.63
molecular function	0.6
protein domain	0.58
histone modification site profile	0.57

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.09   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.09   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (9)

Reactome (7)

WikiPathways (2)

Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular hexose transport	21 targets	R-HSA-189200
Reactome	Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	1 targets	R-HSA-5619068
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Disorders of transmembrane transporters	178 targets	R-HSA-5619115
Reactome	SLC transporter disorders	100 targets	R-HSA-5619102

Name	Explore in Pharos	Explore in Source
Cellular hexose transport	21 targets	R-HSA-189200
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	1 targets	R-HSA-5619068
Disease	1105 targets	R-HSA-1643685
Disorders of transmembrane transporters	178 targets	R-HSA-5619115
SLC transporter disorders	100 targets	R-HSA-5619102

Gene Ontology Terms (9)

Functions (2)

Components (5)

Processes (2)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
carbohydrate:proton symporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
D-glucose transmembrane transporter activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (48)

Explore Interacting Targets

1 – 10 of 48

• See Interactions on String-DB

SRC

Tclin

Family: Kinase

Novelty: 0.00009742

p_int: 0.962835938

p_ni: 0.035103923

p_wrong: 0.002060139

Data Source: BioPlex

FBN1

Tbio

Novelty: 0.00083059

Score: 0.656

Data Source: STRINGDB

SLC16A10

Tbio

Family: Transporter

Novelty: 0.03767726

Score: 0.645

Data Source: STRINGDB

EFEMP2

Tbio

Novelty: 0.01932044

Score: 0.612

Data Source: STRINGDB

ACTA2

Tbio

Novelty: 0.00281551

Score: 0.597

Data Source: STRINGDB

MYH11

Tbio

Novelty: 0.00189652

Score: 0.596

Data Source: STRINGDB

SLC5A10

Tbio

Family: Transporter

Novelty: 0.16789926

Score: 0.595

Data Source: STRINGDB

TGFBR1

Tchem

Family: Kinase

Novelty: 0.00099344

Score: 0.565

Data Source: STRINGDB

COL3A1

Tbio

Novelty: 0.00231183

Score: 0.56

Data Source: STRINGDB

TGFBR2

Tchem

Family: Kinase

Novelty: 0.00128741

Score: 0.554

Data Source: STRINGDB

Publication Statistics

PubMed Score  28.09

PubMed score by year

Reset Zoom

PubTator Score  41.97

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLID

1-70

CYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYE

70-140

AGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLG

140-210

PGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVK

210-280

VAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQD

280-350

SSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFV

350-420

SAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGL

420-490

GFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAAS

490-541

MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAAS

Find similar targets by:

Uniprot Keyword

Complete proteome
Cytoplasm
Disease mutation
Glycoprotein
Membrane
Polymorphism
Reference proteome
Sugar transport
Transmembrane
Transmembrane helix