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Tbio
ELAVL3
ELAV-like protein 3

Protein Summary
Description
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance. A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359227
  • ENSP00000352162
  • ENSG00000196361
  • ENST00000438662
  • ENSP00000390878

Symbol
  • HUC
  • PLE21
  • HUC
  • HUCL
  • PLE21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.78
cellular component
0.73
transcription factor binding site profile
0.69
cell type or tissue
0.65
PubMedID
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.26   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.26   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
22.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
22.9
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (150)
1 – 10 of 150
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 1
Score: 0.489
Data Source: BioPlex,STRINGDB
LGALS4
Tchem
Novelty: 0.00021923
Score: 0.923
Data Source: STRINGDB
GFAP
Tbio
Novelty: 0.00020932
Score: 0.843
Data Source: STRINGDB
NEUROG1
Tbio
Family: TF
Novelty: 0.00494095
Score: 0.782
Data Source: STRINGDB
RBFOX3
Tbio
Novelty: 0.00038317
Score: 0.737
Data Source: STRINGDB
DNAJC2
Tbio
Family: TF
Novelty: 0.01515066
Score: 0.725
Data Source: STRINGDB
L3MBTL1
Tchem
Family: TF; Epigenetic
Novelty: 0.02321712
Score: 0.712
Data Source: STRINGDB
ZPR1
Tbio
Novelty: 0.01893839
Score: 0.695
Data Source: STRINGDB
NEUROD1
Tbio
Family: TF
Novelty: 0.00188624
Score: 0.669
Data Source: STRINGDB
RBFOX1
Tbio
Novelty: 0.00571285
Score: 0.662
Data Source: STRINGDB
Publication Statistics
PubMed Score  635.26

PubMed score by year
PubTator Score  15.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer