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Tchem
MAPK10
Mitogen-activated protein kinase 10

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395157
  • ENSP00000378586
  • ENSG00000109339
  • ENST00000395166
  • ENSP00000378595
  • ENST00000515400
  • ENSP00000424154
  • ENST00000515650
  • ENSP00000492204
  • ENST00000638225
  • ENSP00000491866
  • ENST00000638313
  • ENSP00000492292
  • ENST00000639175
  • ENSP00000491160
  • ENST00000639234
  • ENSP00000491306
  • ENST00000639242
  • ENSP00000491089
  • ENST00000640858
  • ENSP00000491122
  • ENST00000640970
  • ENSP00000492231
  • ENST00000641050
  • ENSP00000493270
  • ENST00000641051
  • ENSP00000493275
  • ENST00000641066
  • ENSP00000493072
  • ENST00000641110
  • ENSP00000493163
  • ENST00000641157
  • ENSP00000493363
  • ENST00000641170
  • ENSP00000493237
  • ENST00000641207
  • ENSP00000493450
  • ENST00000641274
  • ENSP00000492929
  • ENST00000641283
  • ENSP00000493444
  • ENST00000641287
  • ENSP00000493100
  • ENST00000641297
  • ENSP00000493092
  • ENST00000641341
  • ENSP00000493290
  • ENST00000641391
  • ENSP00000493008
  • ENST00000641410
  • ENSP00000493208
  • ENST00000641462
  • ENSP00000493435
  • ENST00000641647
  • ENSP00000493375
  • ENST00000641657
  • ENSP00000493105
  • ENST00000641724
  • ENSP00000493038
  • ENST00000641737
  • ENSP00000493177
  • ENST00000641803
  • ENSP00000493049
  • ENST00000641823
  • ENSP00000493408
  • ENST00000641862
  • ENSP00000493396
  • ENST00000641902
  • ENSP00000492903
  • ENST00000641911
  • ENSP00000493374
  • ENST00000641943
  • ENSP00000492941
  • ENST00000641952
  • ENSP00000493013
  • ENST00000641983
  • ENSP00000493045
  • ENST00000642009
  • ENSP00000493168
  • ENST00000642015
  • ENSP00000493040
  • ENST00000642038
  • ENSP00000492942
  • ENST00000642103
  • ENSP00000493001

Symbol
  • JNK3
  • JNK3A
  • PRKM10
  • SAPK1B
  • JNK3
  • JNK3A
  • PRKM10
  • SAPK1b
  • p493F12
  • p54bSAPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
molecular function
0.99
virus perturbation
0.96
biological process
0.88
pathway
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.8   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 485   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.8   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 159
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (159)
1 – 10 of 159
CHEMBL603469
chemical structure image
CHEMBL1090089
chemical structure image
CHEMBL458997
chemical structure image
CHEMBL2216824
chemical structure image
CHEMBL1230122
chemical structure image
CHEMBL210618
chemical structure image
GNE-3511
chemical structure image
CHEMBL1232769
chemical structure image
CHEMBL1725279
chemical structure image
compound 11 [PMID: 26431428]
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
85.5
testosterone measurement
1
1
1
57.5
triglyceride measurement
2
1
2
39.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
85.5
testosterone measurement
1
57.5
triglyceride measurement
2
39.3
Protein Data Bank (51)
1 – 5 of 51
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (164)
Activation of the AP-1 family of transcription factors (R-HSA-450341)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of the AP-1 family of transcription factors
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (300)
1 – 10 of 300
DDI1
Tbio
Novelty: 0.02845222
p_int: 0.918843494
p_ni: 0.081156506
Score: 0.297
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.869300394
p_ni: 0.130699606
Data Source: BioPlex
CCT6B
Tdark
Novelty: 0.28933315
p_int: 0.781646767
p_ni: 0.218353233
Score: 0.177
Data Source: BioPlex,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.998
Data Source: Reactome,STRINGDB
MAP2K4
Tchem
Family: Kinase
Novelty: 0.00252847
Score: 0.99
Data Source: Reactome,STRINGDB
MAPK8IP1
Tbio
Family: Enzyme
Novelty: 0.00284875
Score: 0.976
Data Source: STRINGDB
CD40
Tchem
Novelty: 0.0002836
Score: 0.976
Data Source: STRINGDB
BCL2L11
Tbio
Novelty: 0.00055914
Score: 0.976
Data Source: STRINGDB
ATF2
Tbio
Family: TF
Novelty: 0.00457832
Score: 0.975
Data Source: Reactome,STRINGDB
DUSP16
Tbio
Family: Enzyme
Novelty: 0.02881973
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  229.80

PubMed score by year
PubTator Score  134.88

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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