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Tclin
KCNQ2
Potassium voltage-gated channel subfamily KQT member 2

Protein Summary
Description
Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873). The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344425
  • ENSP00000345523
  • ENSG00000075043
  • ENST00000344462
  • ENSP00000339611
  • ENST00000359125
  • ENSP00000352035
  • ENST00000360480
  • ENSP00000353668
  • ENST00000626839
  • ENSP00000486706

Symbol
  • EBN
  • BFNC
  • EBN1
  • ENB1
  • HNSPC
  • KV7.2
  • KCNA11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
protein domain
0.92
molecular function
0.88
PubMedID
0.73
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 539.29   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 539.29   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Neuronal System
Protein-Protein Interactions (260)
1 – 10 of 260
GOLM1
Tbio
Novelty: 0.00752112
p_int: 0.987019493
p_ni: 0.012980507
Score: 0.455
Data Source: BioPlex,STRINGDB
NFASC
Tbio
Novelty: 0.00545331
Score: 0.974
Data Source: Reactome,STRINGDB
ANK3
Tbio
Novelty: 0.00429246
Score: 0.97
Data Source: STRINGDB
NRCAM
Tbio
Novelty: 0.00443497
Score: 0.958
Data Source: Reactome,STRINGDB
SPTBN4
Tbio
Novelty: 0.02182293
Score: 0.956
Data Source: STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.948
Data Source: Reactome,STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.948
Data Source: STRINGDB
SPTAN1
Tbio
Novelty: 0.00286901
Score: 0.946
Data Source: Reactome,STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.946
Data Source: STRINGDB
ANK1
Tbio
Novelty: 0.00225305
Score: 0.926
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  539.29

PubMed score by year
PubTator Score  300.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer