Tdark TMEM126B Complex I assembly factor TMEM126B, mitochondrial

Protein Summary

Description

Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I. This gene encodes a mitochondrial transmembrane protein which is a component of the mitochondrial complex I assembly complex. The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It interacts with NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 13. Naturally occurring mutations in this gene are associated with isolated complex I deficiency. A pseudogene of this gene has been defined on chromosome 9. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q8IUX1
• A8K535
• A8MSS0
• Q32Q09
• Q8WVU3
• Q96EP3
• Q9NZ29

Gene Name

• TMEM126B

Ensembl ID

• ENST00000358867
• ENSP00000351737
• ENSG00000171204
• ENST00000393375
• ENSP00000377039
• ENST00000534341
• ENSP00000433471

Symbol

• HT007
• MC1DN29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
cell type or tissue	0.89
transcription factor binding site profile	0.81
disease perturbation	0.62
transcription factor	0.6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.23   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 56   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.23   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (7)

Reactome (5)

WikiPathways (2)

Complex I biogenesis (R-HSA-6799198)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complex I biogenesis	55 targets	R-HSA-6799198
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Complex I biogenesis	55 targets	R-HSA-6799198
Metabolism	2112 targets	R-HSA-1430728
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Gene Ontology Terms (4)

Components (3)

Processes (1)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
mitochondrion	Inferred from Direct Assay (IDA)	HPA
mitochondrial inner membrane	Traceable Author Statement (TAS)	Reactome
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (96)

Explore Interacting Targets

1 – 10 of 96

• See Interactions on String-DB

NDUFAF4

Tclin

Family: Enzyme

Novelty: 0.18993352

p_int: 0.994432807

p_ni: 0.005567172

p_wrong: 2.2e-8

Score: 0.948

Data Source: BioPlex,STRINGDB

ECSIT

Tbio

Novelty: 0.06686583

p_int: 0.988096198

p_ni: 0.011903802

Score: 0.996

Data Source: BioPlex,Reactome,STRINGDB

NDUFA13

Tclin

Family: Enzyme

Novelty: 0.01820177

p_int: 0.970297627

p_ni: 0.029702373

Score: 0.993

Data Source: BioPlex,STRINGDB

NDUFC2

Tclin

Family: Enzyme

Novelty: 0.16071429

p_int: 0.887774657

p_ni: 0.1122252

p_wrong: 1.43e-7

Score: 0.989

Data Source: BioPlex,STRINGDB

APLNR

Tchem

Family: GPCR

Novelty: 0.001441

p_int: 0.883608512

p_ni: 0.116391425

p_wrong: 6.3e-8

Data Source: BioPlex

NDUFS5

Tclin

Family: Enzyme

Novelty: 0.59900166

p_int: 0.836586209

p_ni: 0.163413656

p_wrong: 1.35e-7

Score: 0.906

Data Source: BioPlex,STRINGDB

GLMP

Tdark

Novelty: 0.08368201

p_int: 0.820352146

p_ni: 0.179647847

p_wrong: 7e-9

Data Source: BioPlex

PDCD1

Tclin

Novelty: 0.00079757

p_int: 0.814907641

p_ni: 0.185086296

p_wrong: 0.000006062

Data Source: BioPlex

NDUFB11

Tclin

Family: Enzyme

Novelty: 0.00598699

p_int: 0.791609913

p_ni: 0.208390087

Score: 0.951

Data Source: BioPlex,STRINGDB

NDUFAF1

Tclin

Novelty: 0.0776632

p_int: 0.788862947

p_ni: 0.211137053

Score: 0.996

Data Source: BioPlex,Reactome,STRINGDB

Publication Statistics

PubMed Score  4.23

PubMed score by year

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PubTator Score  3.92

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MVVFGYEAGTKPRDSGVVPVGTEEAPKVFKMAASMHGQPSPSLEDAKLRRPMVIEIIEKNFDYLRKEMTQ

1-70

NIYQMATFGTTAGFSGIFSNFLFRRCFKVKHDALKTYASLATLPFLSTVVTDKLFVIDALYSDNISKENC

70-140

VFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIMFGIL

140-210

NGLYHYAVFEETLEKTIHEE

210-230

MVVFGYEAGTKPRDSGVVPVGTEEAPKVFKMAASMHGQPSPSLEDAKLRRPMVIEIIEKNFDYLRKEMTQNIYQMATFGTTAGFSGIFSNFLFRRCFKVKHDALKTYASLATLPFLSTVVTDKLFVIDALYSDNISKENCVFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIMFGILNGLYHYAVFEETLEKTIHEE

Find similar targets by:

Uniprot Keyword

Alternative splicing
Chaperone
Complete proteome
Membrane
Mitochondrion
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix