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Tchem
CASP8
Caspase-8

Protein Summary
Description
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. This gene encodes a member of the cysteine-aspartic acid prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264274
  • ENSP00000264274
  • ENSG00000064012
  • ENST00000264275
  • ENSP00000264275
  • ENST00000323492
  • ENSP00000325722
  • ENST00000358485
  • ENSP00000351273
  • ENST00000392258
  • ENSP00000376087
  • ENST00000392263
  • ENSP00000376091
  • ENST00000432109
  • ENSP00000412523

Symbol
  • MCH5
  • CAP4
  • MACH
  • MCH5
  • FLICE
  • ALPS2B
  • Casp-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
protein domain
0.97
protein complex
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3758.65   (req: < 5)
Gene RIFs: 519   (req: <= 3)
Antibodies: 1364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3758.65   (req: >= 5)
Gene RIFs: 519   (req: > 3)
Antibodies: 1364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 197
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
85.2
caspase-8 measurement
1
1
1
75.2
triglyceride measurement
1
1
1
70.2
myeloid white cell count
1
1
1
68.2
non-melanoma skin carcinoma
1
1
0
1.2
65.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
85.2
caspase-8 measurement
1
75.2
triglyceride measurement
1
70.2
myeloid white cell count
1
68.2
non-melanoma skin carcinoma
0
1.2
65.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase 8
VGNC:119
746477
Macaque
caspase 8
702781
Mouse
MGI:1261423
12370
Rat
RGD:620945
64044
Dog
caspase 8
VGNC:38736
488473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase 8
Macaque
caspase 8
Mouse
Rat
Dog
caspase 8
Protein Structure (19 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14790-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (117)
Activation, myristolyation of BID and translocation to mitochondria (R-HSA-75108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation, myristolyation of BID and translocation to mitochondria
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
Activation, myristolyation of BID and translocation to mitochondria
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
C-type lectin receptors (CLRs)
Gene Ontology Terms (64)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (418)
1 – 10 of 418
FAS
Tbio
Novelty: 0.00043286
p_int: 0.999999548
p_ni: 4.5e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TNFRSF10A
Tchem
Novelty: 0.0003383
p_int: 0.999999361
p_ni: 6.25e-7
p_wrong: 1.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TNFRSF10B
Tbio
Novelty: 0.00054433
p_int: 0.999999353
p_ni: 6.45e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CFLAR
Tbio
Novelty: 0.00108805
p_int: 0.999978129
p_ni: 0.000021731
p_wrong: 1.41e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CASP7
Tchem
Family: Enzyme
Novelty: 0.00126224
Score: 0.999
Data Source: STRINGDB
CASP6
Tchem
Family: Enzyme
Novelty: 0.00234346
Score: 0.999
Data Source: STRINGDB
BCL2L1
Tchem
Novelty: 0.00018414
Score: 0.999
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.999
Data Source: STRINGDB
FADD
Tbio
Novelty: 0.00137968
Score: 0.999
Data Source: Reactome,STRINGDB
XIAP
Tchem
Family: Enzyme
Novelty: 0.00062268
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  3758.65

PubMed score by year
PubTator Score  3511.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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