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Tbio
HSD17B11
Estradiol 17-beta-dehydrogenase 11

Protein Summary
Description
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358290
  • ENSP00000351035
  • ENSG00000198189

Symbol
  • DHRS8
  • PAN1B
  • SDR16C2
  • DHRS8
  • PAN1B
  • RETSDR2
  • SDR16C2
  • 17BHSD11
  • 17-BETA-HSD11
  • 17-BETA-HSDXI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.86
small molecule perturbation
0.83
transcription factor binding site profile
0.8
gene perturbation
0.74
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
2
2
92.6
lean body mass
1
1
1
42.4
intelligence
1
1
1
15.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
92.6
lean body mass
1
42.4
intelligence
1
15.6
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Estrogen biosynthesis (R-HSA-193144)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Estrogen biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Estrogen biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Protein-Protein Interactions (23)
1 – 10 of 23
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.978528056
p_ni: 0.021471944
Score: 0.183
Data Source: BioPlex,STRINGDB
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.900686232
p_ni: 0.099313768
Score: 0.198
Data Source: BioPlex,STRINGDB
CEBPB
Tbio
Family: TF
Novelty: 0.00068108
Score: 0.737
Data Source: STRINGDB
HSD17B2
Tchem
Family: Enzyme
Novelty: 0.00960865
Score: 0.714
Data Source: STRINGDB
FDX1
Tbio
Novelty: 0.00124491
Score: 0.668
Data Source: STRINGDB
CYP4V2
Tbio
Novelty: 0.00542449
Score: 0.578
Data Source: STRINGDB
HSD17B4
Tbio
Novelty: 0.00547499
Score: 0.565
Data Source: STRINGDB
DCAKD
Tdark
Family: Enzyme
Novelty: 1.5418995
Score: 0.528
Data Source: STRINGDB
NSDHL
Tbio
Family: Enzyme
Novelty: 0.01651408
Score: 0.519
Data Source: STRINGDB
NAA30
Tbio
Family: Enzyme
Novelty: 0.04701961
Score: 0.499
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.42

PubMed score by year
PubTator Score  7.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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